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Please use this identifier to cite or link to this item: https://doi.org/10.1109/MEMSYS.2012.6170300
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dc.titleA study of cancer cell metastasis using microfluidic transmigration device
dc.contributor.authorFu, Y.
dc.contributor.authorVandongen, A.M.J.
dc.contributor.authorBourouina, T.
dc.contributor.authorPark, W.T.
dc.contributor.authorJe, M.Y.
dc.contributor.authorTsai, J.M.
dc.contributor.authorKwong, D.L.
dc.contributor.authorLiu, A.Q.
dc.date.accessioned2014-11-26T09:05:39Z
dc.date.available2014-11-26T09:05:39Z
dc.date.issued2012
dc.identifier.citationFu, Y.,Vandongen, A.M.J.,Bourouina, T.,Park, W.T.,Je, M.Y.,Tsai, J.M.,Kwong, D.L.,Liu, A.Q. (2012). A study of cancer cell metastasis using microfluidic transmigration device. Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS) : 773-776. ScholarBank@NUS Repository. <a href="https://doi.org/10.1109/MEMSYS.2012.6170300" target="_blank">https://doi.org/10.1109/MEMSYS.2012.6170300</a>
dc.identifier.isbn9781467303248
dc.identifier.issn10846999
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/110663
dc.description.abstractMetastasis of cancer cell was studied using microfluidic device. Migration of cells in the microchannel array mimics their transmigration in tissue capillaries during in vivo metastasis. Details of the morphological changes were recorded through high resolution imaging. Results showed that the deformation of cell nucleus is critical for the transmigration of breast cancer cell MDA-MB-231. Condensation of chromatin by drug plicamycinon significantly impaired their deformation abilities and subsequently reduced the transmigration by 2 to 3 fold for microchannel smaller than 10 μm x 5 μm. As transmigration is critical for cancer metastasis, the results will be useful in designing new anti-cancer therapy. © 2012 IEEE.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1109/MEMSYS.2012.6170300
dc.sourceScopus
dc.typeConference Paper
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1109/MEMSYS.2012.6170300
dc.description.sourcetitleProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
dc.description.page773-776
dc.description.codenPMEME
dc.identifier.isiutNOT_IN_WOS
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