Please use this identifier to cite or link to this item: https://doi.org/10.1158/1078-0432.CCR-11-3064
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dc.titleProgenitor-like traits contribute to patient survival and prognosis in oligodendroglial tumors
dc.contributor.authorNg, F.S.-L.
dc.contributor.authorToh, T.B.
dc.contributor.authorTing, E.H.-L.
dc.contributor.authorKoh, G.R.-H.
dc.contributor.authorSandanaraj, E.
dc.contributor.authorPhong, M.
dc.contributor.authorWong, S.S.
dc.contributor.authorLeong, S.H.
dc.contributor.authorKon, O.L.
dc.contributor.authorTucker-Kellogg, G.
dc.contributor.authorNg, W.H.
dc.contributor.authorNg, I.
dc.contributor.authorTang, C.
dc.contributor.authorAng, B.T.
dc.date.accessioned2014-11-26T09:05:03Z
dc.date.available2014-11-26T09:05:03Z
dc.date.issued2012-08-01
dc.identifier.citationNg, F.S.-L., Toh, T.B., Ting, E.H.-L., Koh, G.R.-H., Sandanaraj, E., Phong, M., Wong, S.S., Leong, S.H., Kon, O.L., Tucker-Kellogg, G., Ng, W.H., Ng, I., Tang, C., Ang, B.T. (2012-08-01). Progenitor-like traits contribute to patient survival and prognosis in oligodendroglial tumors. Clinical Cancer Research 18 (15) : 4122-4135. ScholarBank@NUS Repository. https://doi.org/10.1158/1078-0432.CCR-11-3064
dc.identifier.issn10780432
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/110612
dc.description.abstractPurpose: Patient-derived glioma-propagating cells (GPC) contain karyotypic and gene expression profiles that are found in the primary tumor. However, their clinical relevance is unclear. We ask whether GPCs contribute to disease progression and survival outcome in patients with glioma by analyzing gene expression profiles. Experimental Design: We tapped into public sources of GPC gene expression data and derived a gene signature distinguishing oligodendroglial from glioblastoma multiforme (GBM) GPCs. By adapting a method in glioma biology, the Connectivity Map, we interrogated its strength of association in public clinical databases. We validated the top-ranking signaling pathways Wnt, Notch, and TGFβ, in GPCs and primary tumor specimens. Results: We observed that patients with better prognosis correlated with oligodendroglial GPC features and lower tumor grade, and this was independent of the current clinical indicator, 1p/19q status. Patients with better prognosis had proneural tumors whereas the poorly surviving cohort had mesenchymal tumors. In addition, oligodendroglial GPCs were more sensitive to Wnt and Notch inhibition whereas GBM GPCs responded to TGFβR1 inhibition. Conclusions: We provide evidence that GPCs are clinically relevant. In addition, the more favorable prognosis of oligodendroglial tumors over GBM could be recapitulated transcriptomically at the GPC level, underscoring the relevance of this cellular model. Our gene signature detects molecular heterogeneity in oligodendroglial tumors that cannot be accounted for by the 1p/19q status alone, indicating that stem-like traits contribute to clinical status. Collectively, these data highlight the limitation of morphology-based histologic analyses in tumor classification, consequently impacting on treatment decisions. ©2012 AACR.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1158/1078-0432.CCR-11-3064
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1158/1078-0432.CCR-11-3064
dc.description.sourcetitleClinical Cancer Research
dc.description.volume18
dc.description.issue15
dc.description.page4122-4135
dc.description.codenCCREF
dc.identifier.isiut000307503600014
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