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Please use this identifier to cite or link to this item: https://doi.org/10.1128/AAC.02327-12
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dc.titleGrowth inhibition of pathogenic bacteria by sulfonylurea herbicides
dc.contributor.authorKreisberg, J.F.
dc.contributor.authorOng, N.T.
dc.contributor.authorKrishna, A.
dc.contributor.authorJoseph, T.L.
dc.contributor.authorWang, J.
dc.contributor.authorOng, C.
dc.contributor.authorOoi, H.A.
dc.contributor.authorSung, J.C.
dc.contributor.authorSiew, C.C.
dc.contributor.authorChang, G.C.
dc.contributor.authorBiot, F.
dc.contributor.authorCuccui, J.
dc.contributor.authorWren, B.W.
dc.contributor.authorChan, J.
dc.contributor.authorSivalingam, S.P.
dc.contributor.authorZhang, L.-H.
dc.contributor.authorVerma, C.
dc.contributor.authorTan, P.
dc.date.accessioned2014-11-26T09:04:20Z
dc.date.available2014-11-26T09:04:20Z
dc.date.issued2013-03
dc.identifier.citationKreisberg, J.F., Ong, N.T., Krishna, A., Joseph, T.L., Wang, J., Ong, C., Ooi, H.A., Sung, J.C., Siew, C.C., Chang, G.C., Biot, F., Cuccui, J., Wren, B.W., Chan, J., Sivalingam, S.P., Zhang, L.-H., Verma, C., Tan, P. (2013-03). Growth inhibition of pathogenic bacteria by sulfonylurea herbicides. Antimicrobial Agents and Chemotherapy 57 (3) : 1513-1517. ScholarBank@NUS Repository. https://doi.org/10.1128/AAC.02327-12
dc.identifier.issn00664804
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/110554
dc.description.abstractEmerging resistance to current antibiotics raises the need for new microbial drug targets. We show that targeting branchedchain amino acid (BCAA) biosynthesis using sulfonylurea herbicides, which inhibit the BCAA biosynthetic enzyme acetohydroxyacid synthase (AHAS), can exert bacteriostatic effects on several pathogenic bacteria, including Burkholderia pseudomallei, Pseudomonas aeruginosa, and Acinetobacter baumannii. Our results suggest that targeting biosynthetic enzymes like AHAS, which are lacking in humans, could represent a promising antimicrobial drug strategy. Copyright © 2013, American Society for Microbiology.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1128/AAC.02327-12
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1128/AAC.02327-12
dc.description.sourcetitleAntimicrobial Agents and Chemotherapy
dc.description.volume57
dc.description.issue3
dc.description.page1513-1517
dc.description.codenAMACC
dc.identifier.isiut000314968100054
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