Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.exer.2012.12.015
DC FieldValue
dc.titleGenetic contributions to myopic refractive error: Insights from human studies and supporting evidence from animal models
dc.contributor.authorHawthorne, F.A.
dc.contributor.authorYoung, T.L.
dc.date.accessioned2014-11-26T09:04:14Z
dc.date.available2014-11-26T09:04:14Z
dc.date.issued2013-09
dc.identifier.citationHawthorne, F.A., Young, T.L. (2013-09). Genetic contributions to myopic refractive error: Insights from human studies and supporting evidence from animal models. Experimental Eye Research 114 : 141-149. ScholarBank@NUS Repository. https://doi.org/10.1016/j.exer.2012.12.015
dc.identifier.issn00144835
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/110546
dc.description.abstractGenetic studies of both population-based and recruited affected patient cohorts have identified a number of genomic regions and candidate genes that may contribute to myopic development. Scientists have developed animal models of myopia, as collection of affected tissues from patents is impractical. Recent advances in whole exome sequencing technology show promise for further elucidation of disease causing variants as in the recent identification of rare variants within ZNF644 segregating with pathological myopia. We present a review of the current research trends and findings on genetic contributions to myopic refraction including candidate loci for myopic development and their genomic convergence with expression studies of animal models inducing myopic development. © 2013 .
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.exer.2012.12.015
dc.sourceScopus
dc.subjectGene identification
dc.subjectGenetics
dc.subjectGenome-wide associations
dc.subjectLinkage
dc.subjectMapping studies
dc.subjectMyopia
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1016/j.exer.2012.12.015
dc.description.sourcetitleExperimental Eye Research
dc.description.volume114
dc.description.page141-149
dc.description.codenEXERA
dc.identifier.isiut000323084100015
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