Please use this identifier to cite or link to this item: https://doi.org/10.1212/WNL.0b013e3181eccfcd
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dc.titleAnalysis of GWAS-linked loci in Parkinson disease reaffirms PARK16 as a susceptibility locus
dc.contributor.authorTan, E.-K.
dc.contributor.authorKwok, H.-K.
dc.contributor.authorTan, L.C.
dc.contributor.authorZhao, W.-T.
dc.contributor.authorPrakash, K.M.
dc.contributor.authorAu, W.-L.
dc.contributor.authorPavanni, R.
dc.contributor.authorNg, Y.-Y.
dc.contributor.authorSatake, W.
dc.contributor.authorZhao, Y.
dc.contributor.authorToda, T.
dc.contributor.authorLiu, J.-J.
dc.date.accessioned2014-11-26T09:03:36Z
dc.date.available2014-11-26T09:03:36Z
dc.date.issued2010-08-10
dc.identifier.citationTan, E.-K., Kwok, H.-K., Tan, L.C., Zhao, W.-T., Prakash, K.M., Au, W.-L., Pavanni, R., Ng, Y.-Y., Satake, W., Zhao, Y., Toda, T., Liu, J.-J. (2010-08-10). Analysis of GWAS-linked loci in Parkinson disease reaffirms PARK16 as a susceptibility locus. Neurology 75 (6) : 508-512. ScholarBank@NUS Repository. https://doi.org/10.1212/WNL.0b013e3181eccfcd
dc.identifier.issn00283878
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/110487
dc.description.abstractObjective: A genome-wide association study (GWAS) in the Japanese population identified 2 new Parkinson disease (PD) susceptibility loci on 1q32 (PARK16) (OMIM 613164) and BST1. We analyzed single nucleotide polymorphism (SNPs) located at the GWAS-linked loci (PARK16, PARK8, PARK1, and BST1) in a Chinese population and also conducted a meta-analysis in Asians by pooling 2 independent replication studies from Japan. Methods: We conducted an analysis of 13 SNPs associated with PD GWAS-linked loci in 2 case-control cohorts comprised of 1,349 ethnic Chinese subjects. Results: PARK16, PARK8, and PARK1 loci but not BST1 were found to be associated with PD. PARK16 SNPs were associated with a decreased risk while PARK1 and PARK8 SNPs were associated with an increased risk of PD. A pooled analysis of our Chinese cohorts and 2 Japanese replication cohorts involving 1,366 subjects with PD and 16,669 controls revealed robust association with these 3 loci and also BST1. There was a trend toward a stronger protective effect of SNPs at the PARK16 locus in sporadic PD compared to familial cases and in older compared to younger subjects. Conclusions: Our study reaffirms the role of GWAS-linked loci in PD in Asian subjects and the strength of association is similar between Chinese and Japanese subjects. Efforts to elucidate the associated gene within PARK16 locus are warranted. © 2010 by AAN Enterprises, Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1212/WNL.0b013e3181eccfcd
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1212/WNL.0b013e3181eccfcd
dc.description.sourcetitleNeurology
dc.description.volume75
dc.description.issue6
dc.description.page508-512
dc.description.codenNEURA
dc.identifier.isiut000280759600006
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