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Title: Transcallosal diffusion tensor abnormalities in predominant gait disorder parkinsonism
Authors: Chan, L.-L.
Ng, K.-M.
Rumpel, H.
Fook-Chong, S.
Li, H.-H.
Tan, E.-K. 
Keywords: Diffusion tensor imaging
Gait disorder
Parkinson's disease
Postural instability
Issue Date: Jan-2014
Citation: Chan, L.-L., Ng, K.-M., Rumpel, H., Fook-Chong, S., Li, H.-H., Tan, E.-K. (2014-01). Transcallosal diffusion tensor abnormalities in predominant gait disorder parkinsonism. Parkinsonism and Related Disorders 20 (1) : 53-59. ScholarBank@NUS Repository.
Abstract: Background: There have been no previous diffusion tensor imaging (DTI) studies comparing Parkinson's disease (PD) with postural instability and gait disorder (PIGD) parkinsonism. Objective: Utilizing DTI with 2-region tractography, we conducted a case control study to determine if different brain regions representing the neural network of the motor system are differentially affected in PIGD compared to PD and controls. Methods: On a 3T MR machine, using manual ROI (regions of interest) we determined the fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values on DTI in anatomical brain regions representing the extrapyramidal, pyramidal, and transcallosal tracts, aided by 2-region tractography. FA and ADC were correlated with the Tinetti score (measure of gait and balance). Results: Sixty-five subjects (21 PD, 25 PIGD, 19 controls) were included in the analysis. We demonstrated greater ADC abnormalities in the extrapyramidal, pyramidal and transcallosal motor systems in PIGD compared to controls. Multivariate analysis taking into consideration various clinical variables showed that the FA (p=0.02) and ADC (p=0.001) values in the corpus callosum body differentiated PIGD from PD. PIGD with low Tinetti score had a lower FA (p=0.02) and a higher ADC value (corpus callosum body) (p=0.03) compared to those with a high score. Conclusions: We demonstrated for the first time that DTI abnormalities along the transcallosal motor tract in the body of the corpus callosum, but not the substantia nigra, differentiated PIGD from PD, and the degree of corpus callosum body abnormality correlated with the Tinetti score (a measure of risk of falls). © 2013 Elsevier Ltd.
Source Title: Parkinsonism and Related Disorders
ISSN: 13538020
DOI: 10.1016/j.parkreldis.2013.09.017
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