Please use this identifier to cite or link to this item: https://doi.org/10.1002/ajmg.b.30754
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dc.titleSocial support in older individuals: The role of the BDNF Val66Met polymorphism
dc.contributor.authorTaylor, W.D.
dc.contributor.authorZüchner, S.
dc.contributor.authorMcQuoid, D.R.
dc.contributor.authorSteffens, D.C.
dc.contributor.authorBlazer, D.G.
dc.contributor.authorKrishnan, K.R.R.
dc.date.accessioned2014-11-26T08:30:37Z
dc.date.available2014-11-26T08:30:37Z
dc.date.issued2008-10-05
dc.identifier.citationTaylor, W.D., Züchner, S., McQuoid, D.R., Steffens, D.C., Blazer, D.G., Krishnan, K.R.R. (2008-10-05). Social support in older individuals: The role of the BDNF Val66Met polymorphism. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics 147 (7) : 1205-1212. ScholarBank@NUS Repository. https://doi.org/10.1002/ajmg.b.30754
dc.identifier.issn15524841
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/110281
dc.description.abstractAlthough often viewed as a purely environmental construct, perception of social support may be influenced by genetic factors. This study examined the relationship between the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism andsocial support measures in older subjects. The sample consisted of 243 depressed and 115 non-depressed older subjects, age 60 years or older; 233 were Val66 allele homozygotes, while 125 were Met66 allele carriers. All subjects completed clinical assessments, including a self-report questionnaire assessing four social support domains, and provided blood for genotyping. Statistical models examined the relationship between scale scores of social support and BDNF Val66Met genotype, while controlling for presence or absence of major depressive disorder and other demographic factors significantly associated with social support. As social support measures were not normally distributed, log-transformed scores were examined. After controlling for diagnosis and education level, the Met66 allele was associated with lower levels of subjective social support (F1,357 = 5.33, P = 0.0216) and a trend for fewer social interactions (F1,357 = 3.66, P = 0.0567). Toour knowledge, this is the first report associating a measure of social support with a genetic polymorphism. This supports previous work that genetic factors may influence social support perception. Further work is needed to determine the generalizability of this finding to the broader population, as well as its significance for clinical outcomes. © 2008 Wiley-Liss, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/ajmg.b.30754
dc.sourceScopus
dc.subjectAging
dc.subjectDepression
dc.subjectGeriatrics
dc.subjectPolymorphism
dc.subjectSingle nucleotide
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1002/ajmg.b.30754
dc.description.sourcetitleAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
dc.description.volume147
dc.description.issue7
dc.description.page1205-1212
dc.description.codenAJMGE
dc.identifier.isiut000259979500027
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