Please use this identifier to cite or link to this item:
https://doi.org/10.1371/journal.pone.0067058
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dc.title | Reversible Femtosecond Laser-Assisted Myopia Correction: A Non-Human Primate Study of Lenticule Re-Implantation after Refractive Lenticule Extraction | |
dc.contributor.author | Riau, A.K. | |
dc.contributor.author | Angunawela, R.I. | |
dc.contributor.author | Chaurasia, S.S. | |
dc.contributor.author | Lee, W.S. | |
dc.contributor.author | Tan, D.T. | |
dc.contributor.author | Mehta, J.S. | |
dc.date.accessioned | 2014-11-26T08:30:20Z | |
dc.date.available | 2014-11-26T08:30:20Z | |
dc.date.issued | 2013-06-24 | |
dc.identifier.citation | Riau, A.K., Angunawela, R.I., Chaurasia, S.S., Lee, W.S., Tan, D.T., Mehta, J.S. (2013-06-24). Reversible Femtosecond Laser-Assisted Myopia Correction: A Non-Human Primate Study of Lenticule Re-Implantation after Refractive Lenticule Extraction. PLoS ONE 8 (6) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0067058 | |
dc.identifier.issn | 19326203 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/110255 | |
dc.description.abstract | LASIK (laser-assisted in situ keratomileusis) is a common laser refractive procedure for myopia and astigmatism, involving permanent removal of anterior corneal stromal tissue by excimer ablation beneath a hinged flap. Correction of refractive error is achieved by the resulting change in the curvature of the cornea and is limited by central corneal thickness, as a thin residual stromal bed may result in biomechanical instability of the cornea. A recently developed alternative to LASIK called Refractive Lenticule Extraction (ReLEx) utilizes solely a femtosecond laser (FSL) to incise an intrastromal refractive lenticule (RL), which results in reshaping the corneal curvature and correcting the myopia and/or astigmatism. As the RL is extracted intact in the ReLEx, we hypothesized that it could be cryopreserved and re-implanted at a later date to restore corneal stromal volume, in the event of keratectasia, making ReLEx a potentially reversible procedure, unlike LASIK. In this study, we re-implanted cryopreserved RLs in a non-human primate model of ReLEx. Mild intrastromal haze, noted during the first 2 weeks after re-implantation, subsided after 8 weeks. Refractive parameters including corneal thickness, anterior curvature and refractive error indices were restored to near pre-operative values after the re-implantation. Immunohistochemistry revealed no myofibroblast formation or abnormal collagen type I expression after 8 weeks, and a significant attenuation of fibronectin and tenascin expression from week 8 to 16 after re-implantation. In addition, keratocyte re-population could be found along the implanted RL interfaces. Our findings suggest that RL cryopreservation and re-implantation after ReLEx appears feasible, suggesting the possibility of potential reversibility of the procedure, and possible future uses of RLs in treating other corneal disorders and refractive errors. © 2013 Riau et al. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1371/journal.pone.0067058 | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE | |
dc.description.doi | 10.1371/journal.pone.0067058 | |
dc.description.sourcetitle | PLoS ONE | |
dc.description.volume | 8 | |
dc.description.issue | 6 | |
dc.description.page | - | |
dc.description.coden | POLNC | |
dc.identifier.isiut | 000321738400099 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications |
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10_1371_journal_pone_0067058.pdf | 7.54 MB | Adobe PDF | OPEN | Published | View/Download |
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