Please use this identifier to cite or link to this item: https://doi.org/10.1039/c2lc40477j
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dc.titleNuclear deformation during breast cancer cell transmigration
dc.contributor.authorFu, Y.
dc.contributor.authorChin, L.K.
dc.contributor.authorBourouina, T.
dc.contributor.authorLiu, A.Q.
dc.contributor.authorVandongen, A.M.J.
dc.date.accessioned2014-11-26T08:29:39Z
dc.date.available2014-11-26T08:29:39Z
dc.date.issued2012-10-07
dc.identifier.citationFu, Y., Chin, L.K., Bourouina, T., Liu, A.Q., Vandongen, A.M.J. (2012-10-07). Nuclear deformation during breast cancer cell transmigration. Lab on a Chip - Miniaturisation for Chemistry and Biology 12 (19) : 3774-3778. ScholarBank@NUS Repository. https://doi.org/10.1039/c2lc40477j
dc.identifier.issn14730197
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/110196
dc.description.abstractMetastasis is the main cause of cancer mortality. During this process, cancer cells dislodge from a primary tumor, enter the circulation and form secondary tumors in distal organs. It is poorly understood how these cells manage to cross the tight syncytium of endothelial cells that lines the capillaries. Such capillary transmigration would require a drastic change in cell shape. We have therefore developed a microfluidic platform to study the transmigration of cancer cells. The device consists of an array of microchannels mimicking the confined spaces encountered. A thin glass coverslip bottom allows high resolution imaging of cell dynamics. We show that nuclear deformation is a critical and rate-limiting step for transmigration of highly metastatic human breast cancer cells. Transmigration was significantly reduced following the treatment with a protein methyltransferase inhibitor, suggesting that chromatin condensation might play an important role. Since transmigration is critical for cancer metastasis, this new platform may be useful for developing improved cancer therapies. © 2012 The Royal Society of Chemistry.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1039/c2lc40477j
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1039/c2lc40477j
dc.description.sourcetitleLab on a Chip - Miniaturisation for Chemistry and Biology
dc.description.volume12
dc.description.issue19
dc.description.page3774-3778
dc.description.codenLCAHA
dc.identifier.isiut000307792500029
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