Please use this identifier to cite or link to this item: https://doi.org/10.1007/s00296-012-2602-2
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dc.titleMajor trends in the manifestations and treatment of rheumatoid arthritis in a multiethnic cohort in Singapore
dc.contributor.authorKoh, E.T.
dc.contributor.authorTan, J.W.L.
dc.contributor.authorThong, B.Y.-H.
dc.contributor.authorTeh, C.L.
dc.contributor.authorLian, T.Y.
dc.contributor.authorLaw, W.G.
dc.contributor.authorEarnest, A.
dc.contributor.authorKong, K.O.
dc.contributor.authorLau, T.C.
dc.contributor.authorCheng, Y.K.
dc.contributor.authorHowe, H.S.
dc.contributor.authorYong, W.H.
dc.contributor.authorChia, F.L.-A.
dc.contributor.authorChng, H.H.
dc.contributor.authorLeong, K.P.
dc.date.accessioned2014-11-26T08:29:18Z
dc.date.available2014-11-26T08:29:18Z
dc.date.issued2013-07
dc.identifier.citationKoh, E.T., Tan, J.W.L., Thong, B.Y.-H., Teh, C.L., Lian, T.Y., Law, W.G., Earnest, A., Kong, K.O., Lau, T.C., Cheng, Y.K., Howe, H.S., Yong, W.H., Chia, F.L.-A., Chng, H.H., Leong, K.P. (2013-07). Major trends in the manifestations and treatment of rheumatoid arthritis in a multiethnic cohort in Singapore. Rheumatology International 33 (7) : 1693-1703. ScholarBank@NUS Repository. https://doi.org/10.1007/s00296-012-2602-2
dc.identifier.issn01728172
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/110165
dc.description.abstractWe analyzed the epidemiological changes of rheumatoid arthritis (RA) over three decades using patients from a single center in Singapore. All patients who fulfill the 1987 American College of Rheumatology criteria for RA were invited to enroll in a prospective disease registry. We analyzed the patient demographics, disease manifestation, management and patient-reported outcomes, including quality of life (QoL), in the three categories according to the year of disease onset: before 1989 (group I), 1990-1999 (group II) and after 2000 (group III). There were 1,153 patients with 231, 532 and 390 in groups I, II and III, respectively. The mean disease durations were 25, 12 and 4.8 years, respectively. The majority was female (84.1 %) and Chinese (76.6 %) with no socio-demographic differences across the three periods. The age of onset rises and the prevalence of rheumatoid factor falls with the proximity of disease onset. Patients with most recent disease onset had the earliest access to the rheumatologist. They also had the highest tender and swollen joint counts, lowest deformed joint count and highest remission rate. Patients in group I report better mental and emotional QoL though many developed marked disability. We have documented changes of the manifestations of RA that are dependent and independent of improved treatment. Significant differences in accessibility to the rheumatologist, RA activity, functional capacity, quality of life and comorbidities were seen in subsequent cohorts due to treatment evolution and more efficient healthcare delivery. © 2012 Springer-Verlag Berlin Heidelberg.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1007/s00296-012-2602-2
dc.sourceScopus
dc.subjectAsian
dc.subjectEpidemiology
dc.subjectFunctional status
dc.subjectOutcome measures
dc.subjectQuality of life
dc.subjectRheumatoid arthritis
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1007/s00296-012-2602-2
dc.description.sourcetitleRheumatology International
dc.description.volume33
dc.description.issue7
dc.description.page1693-1703
dc.description.codenRHIND
dc.identifier.isiut000321259500006
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