Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ahj.2010.09.008
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dc.titleLipid-lowering intensification and low-density lipoprotein cholesterol achievement from hospital admission to 1-year follow-up after an acute coronary syndrome event: Results from the medications applied and sustained over time (MAINTAIN) registry
dc.contributor.authorMelloni, C.
dc.contributor.authorShah, B.R.
dc.contributor.authorOu, F.-S.
dc.contributor.authorRoe, M.T.
dc.contributor.authorSmith Jr., S.C.
dc.contributor.authorPollack Jr., C.V.
dc.contributor.authorOhman, M.
dc.contributor.authorGibler, W.B.
dc.contributor.authorPeterson, E.D.
dc.contributor.authorAlexander, K.P.
dc.date.accessioned2014-11-26T08:29:14Z
dc.date.available2014-11-26T08:29:14Z
dc.date.issued2010-12
dc.identifier.citationMelloni, C., Shah, B.R., Ou, F.-S., Roe, M.T., Smith Jr., S.C., Pollack Jr., C.V., Ohman, M., Gibler, W.B., Peterson, E.D., Alexander, K.P. (2010-12). Lipid-lowering intensification and low-density lipoprotein cholesterol achievement from hospital admission to 1-year follow-up after an acute coronary syndrome event: Results from the medications applied and sustained over time (MAINTAIN) registry. American Heart Journal 160 (6) : 1121-1129.e1. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ahj.2010.09.008
dc.identifier.issn00028703
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/110160
dc.description.abstractBackground: Current American College of Cardiology/American Heart Association guidelines recommend initiation or intensification of statin therapy to achieve low-density lipoprotein cholesterol (LDL-C) goals after an acute coronary syndrome (ACS), yet little is known about the actual practice of intensifying lipid-lowering (LL) therapy and LDL-C achievement from hospital admission to 1-year follow-up. Methods: The MAINTAIN registry enrolled ACS patients from January 2006 through September 2007, collecting data on statin formulation, dose, and lipid profiles at both baseline and 12 months. Statin intensity (estimated LDL-C lowering) was categorized by formulation and dose as either moderate (100 mg/dL at admission, only 37% (n = 38) had their LL therapy intensified. Among 382 patients with 12 months of data, 89% (n = 341) were discharged on a statin. Of these, 89% were still on a statin at 12-month follow-up. A LDL-C goal of ≤100 mg/dL was achieved in 71% of patients, but the optional LDL-C goal ≤70 mg/dL was achieved in only 31%. Conclusions: Most high-risk ACS patients are prescribed statin therapy at hospital discharge and remain on therapy at 12-month follow-up. Despite this, the LDL-C goal of ≤70 mg/dL is achieved in a small minority. There is substantial opportunity to intensify LL therapy after ACS to achieve guideline LDL-C goals and prevent future morbidity and mortality. © 2010 Mosby, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.ahj.2010.09.008
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1016/j.ahj.2010.09.008
dc.description.sourcetitleAmerican Heart Journal
dc.description.volume160
dc.description.issue6
dc.description.page1121-1129.e1
dc.description.codenAHJOA
dc.identifier.isiut000285187600024
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