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Title: Cell therapy for bone regeneration-bench to bedside
Authors: Lee, K.
Chan, C.K. 
Patil, N.
Goodman, S.B.
Keywords: Bone regeneration
Stem cells
Issue Date: Apr-2009
Citation: Lee, K., Chan, C.K., Patil, N., Goodman, S.B. (2009-04). Cell therapy for bone regeneration-bench to bedside. Journal of Biomedical Materials Research - Part B Applied Biomaterials 89 (1) : 252-263. ScholarBank@NUS Repository.
Abstract: The concept of bone tissue engineering, which began in the early 1980s, has seen tremendous growth in the numbers of research studies. One of the key areas of research has been in the field of mesenchymal stem cells, where the challenge is to produce the perfect tissue-engineered bone construct. This practical review summarizes basic and applied state-of-the-art research in the area of ntesenchymal stem cells, and highlights the important translational research that has already been initiated. The topics that will be covered include the sources of stem cells in use, scaffolds, gene therapy, clinical applications in nonunions, tumors, osteonecrosis, revision arthroplasties, and spine fusion. Although significant challenges remain, there exists an exceptional opportunity to translate basic research in mesenchymal stem cell technologies into viable clinical treatments for bone regeneration. © 2008 Wiley Periodicals. Inc.
Source Title: Journal of Biomedical Materials Research - Part B Applied Biomaterials
ISSN: 15524973
DOI: 10.1002/jbm.b.31199
Appears in Collections:Staff Publications

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