Please use this identifier to cite or link to this item: https://doi.org/10.1111/j.1399-3038.2011.01149.x
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dc.titleThe effect of Kawasaki disease on childhood allergies - a sibling control study
dc.contributor.authorLiew, W.K.
dc.contributor.authorLim, C.W.T.
dc.contributor.authorTan, T.H.
dc.contributor.authorWong, K.Y.
dc.contributor.authorTai, B.C.
dc.contributor.authorQuek, S.C.
dc.contributor.authorvan Bever, H.
dc.date.accessioned2014-11-26T07:48:50Z
dc.date.available2014-11-26T07:48:50Z
dc.date.issued2011-08
dc.identifier.citationLiew, W.K., Lim, C.W.T., Tan, T.H., Wong, K.Y., Tai, B.C., Quek, S.C., van Bever, H. (2011-08). The effect of Kawasaki disease on childhood allergies - a sibling control study. Pediatric Allergy and Immunology 22 (5) : 488-493. ScholarBank@NUS Repository. https://doi.org/10.1111/j.1399-3038.2011.01149.x
dc.identifier.issn09056157
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/109690
dc.description.abstractObjective: Kawasaki disease (KD) is a multisystem inflammatory vasculitis of childhood, with widespread T-helper cell type 1 immune activation. We hypothesize that children who suffered from KD will have a lower risk of developing allergic diseases. Study design: This was a cross-sectional study, recruiting children with a history of KD, together with well sibling controls. All children underwent the standardized core ISAAC questionnaire for allergy, physical examination and skin prick test evaluation. McNemar's test was employed to evaluate the effect of Kawasaki disease on allergy. Multivariable analysis based on mixed-effects logistic regression model was used to adjust for potential confounding effect of age and gender. Results: One hundred and eighty-six children (93 KD sibling pairs) completed the above evaluation. Allergic rhinitis was more common in patients with KD (crude OR 2.40; 95% CI 1.11-5.62, p=0.024) when compared with controls. The effect was further intensified after accounting for the potential confounding effect of age and gender (adjusted OR=2.90; 95% CI 1.27-6.60). Children in whom KD occurred beyond the age of 12months had more allergic rhinitis (crude OR 4.00, 95% CI 1.29-16.44, p=0.012), 'any' allergies (crude OR 3.75, 95% CI 1.19-15.52, p=0.019) and Blomia tropicalis sensitization (crude OR 2.57, 95% CI 1.02-7.28, p=0.043) when compared with their sibling controls. Interestingly, children in whom KD course resulted in no coronary artery abnormalities have more allergic rhinitis (crude OR 8.50, 95% CI 2.02-75.85, p=0.003) and 'any' allergies (crude OR 5.00, 95% CI 1.41-26.94, p=0.011), when compared with their sibling controls. Conclusion: Kawasaki disease may be a risk factor for subsequent allergic diseases. We postulate that KD occurs more frequently in children at risk of immune disequilibrium, with an abnormal inflammatory response initially, and subsequently more allergic manifestations. © 2011 John Wiley & Sons A/S.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1111/j.1399-3038.2011.01149.x
dc.sourceScopus
dc.subjectAllergies
dc.subjectChildren
dc.subjectKawasaki disease
dc.typeArticle
dc.contributor.departmentEPIDEMIOLOGY & PUBLIC HEALTH
dc.description.doi10.1111/j.1399-3038.2011.01149.x
dc.description.sourcetitlePediatric Allergy and Immunology
dc.description.volume22
dc.description.issue5
dc.description.page488-493
dc.description.codenPALUE
dc.identifier.isiut000292931300006
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