Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/109568
DC FieldValue
dc.titleReactive oxygen species-mediated regulation of the Na+- H+ exchanger 1 gene expression connects intracellular redox status with cells' sensitivity to death triggers
dc.contributor.authorAkram, S.
dc.contributor.authorTeong, H.F.C.
dc.contributor.authorFliegel, L.
dc.contributor.authorPervaiz, S.
dc.contributor.authorClément, M.V.
dc.date.accessioned2014-11-26T07:47:27Z
dc.date.available2014-11-26T07:47:27Z
dc.date.issued2006-04
dc.identifier.citationAkram, S., Teong, H.F.C., Fliegel, L., Pervaiz, S., Clément, M.V. (2006-04). Reactive oxygen species-mediated regulation of the Na+- H+ exchanger 1 gene expression connects intracellular redox status with cells' sensitivity to death triggers. Cell Death and Differentiation 13 (4) : 628-641. ScholarBank@NUS Repository.
dc.identifier.issn13509047
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/109568
dc.description.abstractWe have previously demonstrated that a slight increase in intracellular superoxide (O2 •-) anion confers resistance to death stimuli. Using pharmacological and molecular approaches to manipulate intracellular O2 •-, here we report that an increase in intracellular O2 •- anion induces Na+/H+ exchanger 1 (NHE-1) gene promoter activity resulting in increased NHE-1 protein expression, which strongly correlates with the resistance of cells to death stimuli. In contrast, exposure to exogenous hydrogen peroxide suppressed NHE-1 promoter activity and gene expression, and increased cell sensitivity to death triggers. Furthermore, the increase in cell sensitivity to death upon downregulation of NHE-1 gene expression correlates with reduced capacity of cells to recover from an acid load, while survival upon overexpression of NHE-1 appears independent of its pump activity. These findings indicate that NHE-1 is a redox-regulated gene, and provide a novel intracellular target for the redox control of cell death sensitivity. © 2006 Nature Publishing Group. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1038/sj.cdd.4401775
dc.sourceScopus
dc.subjectCell death
dc.subjectHydrogen peroxide
dc.subjectNa+/H+ exchanger NHE-1
dc.subjectRac1
dc.subjectSuperoxide
dc.typeArticle
dc.contributor.departmentBIOCHEMISTRY
dc.description.sourcetitleCell Death and Differentiation
dc.description.volume13
dc.description.issue4
dc.description.page628-641
dc.description.codenCDDIE
dc.identifier.isiut000236040800009
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