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Please use this identifier to cite or link to this item: https://doi.org/10.1074/jbc.M113.475798
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dc.titlePara-aminosalicylic acid is a prodrug targeting dihydrofolate reductase in mycobacterium tuberculosis
dc.contributor.authorZheng, J.
dc.contributor.authorRubin, E.J.
dc.contributor.authorBifani, P.
dc.contributor.authorMathys, V.
dc.contributor.authorLim, V.
dc.contributor.authorAu, M.
dc.contributor.authorJang, J.
dc.contributor.authorNam, J.
dc.contributor.authorDick, T.
dc.contributor.authorWalker, J.R.
dc.contributor.authorPethe, K.
dc.contributor.authorCamacho, L.R.
dc.date.accessioned2014-11-26T07:46:45Z
dc.date.available2014-11-26T07:46:45Z
dc.date.issued2013-08-09
dc.identifier.citationZheng, J., Rubin, E.J., Bifani, P., Mathys, V., Lim, V., Au, M., Jang, J., Nam, J., Dick, T., Walker, J.R., Pethe, K., Camacho, L.R. (2013-08-09). Para-aminosalicylic acid is a prodrug targeting dihydrofolate reductase in mycobacterium tuberculosis. Journal of Biological Chemistry 288 (32) : 23447-23456. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M113.475798
dc.identifier.issn00219258
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/109505
dc.description.abstractBackground: PAS is an antimycobacterial whose mechanism(s) of action remains elusive. Results: PAS is incorporated into the folate pathway by DHPS-DHFS, generating an anti-metabolite. DHFS and RibD are associated with PAS resistance. Conclusion: Hydroxyl dihydrofolate inhibits DHFR. folC and ribD are drug target genes for identification of clinical PAS resistance. Significance: Metabolite analog incorporation into essential biosynthetic pathways is promising for developing antibacterials. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1074/jbc.M113.475798
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentMICROBIOLOGY
dc.description.doi10.1074/jbc.M113.475798
dc.description.sourcetitleJournal of Biological Chemistry
dc.description.volume288
dc.description.issue32
dc.description.page23447-23456
dc.description.codenJBCHA
dc.identifier.isiut000330598200051
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