Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.eururo.2010.11.031
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dc.titleNRAMP1 and hGPX1 gene polymorphism and response to bacillus Calmette-Guérin therapy for bladder cancer
dc.contributor.authorChiong, E.
dc.contributor.authorKesavan, A.
dc.contributor.authorMahendran, R.
dc.contributor.authorChan, Y.H.
dc.contributor.authorSng, J.H.
dc.contributor.authorLim, Y.K.
dc.contributor.authorKamaraj, R.
dc.contributor.authorTan, T.M.C.
dc.contributor.authorEsuvaranathan, K.
dc.date.accessioned2014-11-26T07:46:38Z
dc.date.available2014-11-26T07:46:38Z
dc.date.issued2011-03
dc.identifier.citationChiong, E., Kesavan, A., Mahendran, R., Chan, Y.H., Sng, J.H., Lim, Y.K., Kamaraj, R., Tan, T.M.C., Esuvaranathan, K. (2011-03). NRAMP1 and hGPX1 gene polymorphism and response to bacillus Calmette-Guérin therapy for bladder cancer. European Urology 59 (3) : 430-437. ScholarBank@NUS Repository. https://doi.org/10.1016/j.eururo.2010.11.031
dc.identifier.issn03022838
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/109495
dc.description.abstractBackground: The natural resistance-associated macrophage protein 1 (NRAMP1) gene is associated with susceptibility to Mycobacterium tuberculosis in humans and to bacillus Calmette-Guérin (BCG) in mice. The detoxification enzyme, human glutathione peroxidase 1 (hGPX1), is associated with recurrence of bladder cancer (BCa). Objective: To determine whether NRAMP1 and hGPX1 gene polymorphisms correlate with response to BCG immunotherapy for non-muscle-invasive BCa (NMIBC). Design, setting, and participants: DNA was obtained from the peripheral blood of 99 NMIBC patients who were prospectively randomized to receive postresection intravesical BCG (81 mg [n = 50] or 27 mg [n = 19]) or BCG (27 mg) with interferon alpha (IFN-α; n = 30). The median follow-up time was 60 mo. Intervention: Intravesical BCG or BCG-IFN-α. Measurements: Restriction fragment length polymorphism (RFLP) analysis was performed to identify polymorphisms in the NRAMP1 promoter region (GT repeat number) and at position 543 (aspartate [D] and/or asparagine [N] expression) within the NRAMP1 protein (D543N) and position 198 (proline and/or leucine expression) within the hGPX1 protein (Pro198Leu). Data were analyzed using χ2 analysis, multivariate analysis, and Kaplan-Meier curves. Results and limitations: On univariate analysis, the NRAMP1 D543N G:G genotype had decreased cancer-specific survival (CSS; p = 0.036). The hGPX1 CT genotype (Pro-Leu) had decreased recurrence time (p = 0.03) after BCG therapy. On multivariate analysis, patients with the NRAMP1 D543N G:G genotype and allele 3 (GT)n polymorphism had decreased recurrence time (p = 0.014 and p = 0.03) after BCG therapy. The limitation of this study was its small sample size. Conclusions: Polymorphisms of the NRAMP1 and hGPX1 genes may be associated with recurrence of BCa after BCG immunotherapy. © 2010 European Association of Urology. Published by Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.eururo.2010.11.031
dc.sourceScopus
dc.subjectBacillus Calmette-Guérin
dc.subjectBladder cancer
dc.subjectGene polymorphism
dc.typeArticle
dc.contributor.departmentBIOCHEMISTRY
dc.contributor.departmentSURGERY
dc.description.doi10.1016/j.eururo.2010.11.031
dc.description.sourcetitleEuropean Urology
dc.description.volume59
dc.description.issue3
dc.description.page430-437
dc.description.codenEUURA
dc.identifier.isiut000286658600029
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