Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.eururo.2010.11.031
DC Field | Value | |
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dc.title | NRAMP1 and hGPX1 gene polymorphism and response to bacillus Calmette-Guérin therapy for bladder cancer | |
dc.contributor.author | Chiong, E. | |
dc.contributor.author | Kesavan, A. | |
dc.contributor.author | Mahendran, R. | |
dc.contributor.author | Chan, Y.H. | |
dc.contributor.author | Sng, J.H. | |
dc.contributor.author | Lim, Y.K. | |
dc.contributor.author | Kamaraj, R. | |
dc.contributor.author | Tan, T.M.C. | |
dc.contributor.author | Esuvaranathan, K. | |
dc.date.accessioned | 2014-11-26T07:46:38Z | |
dc.date.available | 2014-11-26T07:46:38Z | |
dc.date.issued | 2011-03 | |
dc.identifier.citation | Chiong, E., Kesavan, A., Mahendran, R., Chan, Y.H., Sng, J.H., Lim, Y.K., Kamaraj, R., Tan, T.M.C., Esuvaranathan, K. (2011-03). NRAMP1 and hGPX1 gene polymorphism and response to bacillus Calmette-Guérin therapy for bladder cancer. European Urology 59 (3) : 430-437. ScholarBank@NUS Repository. https://doi.org/10.1016/j.eururo.2010.11.031 | |
dc.identifier.issn | 03022838 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/109495 | |
dc.description.abstract | Background: The natural resistance-associated macrophage protein 1 (NRAMP1) gene is associated with susceptibility to Mycobacterium tuberculosis in humans and to bacillus Calmette-Guérin (BCG) in mice. The detoxification enzyme, human glutathione peroxidase 1 (hGPX1), is associated with recurrence of bladder cancer (BCa). Objective: To determine whether NRAMP1 and hGPX1 gene polymorphisms correlate with response to BCG immunotherapy for non-muscle-invasive BCa (NMIBC). Design, setting, and participants: DNA was obtained from the peripheral blood of 99 NMIBC patients who were prospectively randomized to receive postresection intravesical BCG (81 mg [n = 50] or 27 mg [n = 19]) or BCG (27 mg) with interferon alpha (IFN-α; n = 30). The median follow-up time was 60 mo. Intervention: Intravesical BCG or BCG-IFN-α. Measurements: Restriction fragment length polymorphism (RFLP) analysis was performed to identify polymorphisms in the NRAMP1 promoter region (GT repeat number) and at position 543 (aspartate [D] and/or asparagine [N] expression) within the NRAMP1 protein (D543N) and position 198 (proline and/or leucine expression) within the hGPX1 protein (Pro198Leu). Data were analyzed using χ2 analysis, multivariate analysis, and Kaplan-Meier curves. Results and limitations: On univariate analysis, the NRAMP1 D543N G:G genotype had decreased cancer-specific survival (CSS; p = 0.036). The hGPX1 CT genotype (Pro-Leu) had decreased recurrence time (p = 0.03) after BCG therapy. On multivariate analysis, patients with the NRAMP1 D543N G:G genotype and allele 3 (GT)n polymorphism had decreased recurrence time (p = 0.014 and p = 0.03) after BCG therapy. The limitation of this study was its small sample size. Conclusions: Polymorphisms of the NRAMP1 and hGPX1 genes may be associated with recurrence of BCa after BCG immunotherapy. © 2010 European Association of Urology. Published by Elsevier B.V. All rights reserved. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.eururo.2010.11.031 | |
dc.source | Scopus | |
dc.subject | Bacillus Calmette-Guérin | |
dc.subject | Bladder cancer | |
dc.subject | Gene polymorphism | |
dc.type | Article | |
dc.contributor.department | BIOCHEMISTRY | |
dc.contributor.department | SURGERY | |
dc.description.doi | 10.1016/j.eururo.2010.11.031 | |
dc.description.sourcetitle | European Urology | |
dc.description.volume | 59 | |
dc.description.issue | 3 | |
dc.description.page | 430-437 | |
dc.description.coden | EUURA | |
dc.identifier.isiut | 000286658600029 | |
Appears in Collections: | Staff Publications |
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