Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bbrc.2010.08.126
Title: MHC class II-associated invariant chain (Ii) modulates dendritic cells-derived microvesicles (DCMV)-mediated activation of microglia
Authors: Teo, B.H.D.
Wong, S.H. 
Keywords: Dendritic cells
Invariant chain
Microglia
Microvesicles
NF-κB
Issue Date: 1-Oct-2010
Citation: Teo, B.H.D., Wong, S.H. (2010-10-01). MHC class II-associated invariant chain (Ii) modulates dendritic cells-derived microvesicles (DCMV)-mediated activation of microglia. Biochemical and Biophysical Research Communications 400 (4) : 673-678. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbrc.2010.08.126
Abstract: Dendritic cells (DC) - the sentinels of the immune system - play an important role in the maintenance of tolerance and induction of immunity. However, in autoimmune diseases, DC initiate the diseases by presenting self antigens to autoreactive T cells, causing the immune system to mount a response against the body. An example is multiple sclerosis (MS) and its corresponding animal model, experimental autoimmune encephalomyelitis (EAE). During inflammation of the central nervous system (CNS), DC are recruited to activate autoreactive T cells. Microglia - resident mononuclear phagocytes of the brain - also play a role in the pathogenesis of the disease. In this study, we demonstrated that microvesicles derived from DC (DCMV) induced the activation of NF-κB in microglia. Furthermore, MHC class II-associated invariant chain (Ii), also known as CD74, was specifically recruited to DCMV and interestingly, was able to enhance the DCMV-mediated activation of NF-κB in microglia. Thus, this study emphasizes the role of microvesicles and Ii in the communication between DC and microglia. © 2010 Elsevier Inc.
Source Title: Biochemical and Biophysical Research Communications
URI: http://scholarbank.nus.edu.sg/handle/10635/109460
ISSN: 0006291X
DOI: 10.1016/j.bbrc.2010.08.126
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