Please use this identifier to cite or link to this item:
https://doi.org/10.1083/jcb.200602149
DC Field | Value | |
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dc.title | IKKβ programs to turn on the GADD45α-MKK4-JNK apoptotic cascade specifically via p50 NF-κB in arsenite response | |
dc.contributor.author | Song, L. | |
dc.contributor.author | Li, J. | |
dc.contributor.author | Zhang, D. | |
dc.contributor.author | Liu, Z.-G. | |
dc.contributor.author | Ye, J. | |
dc.contributor.author | Zhan, Q. | |
dc.contributor.author | Shen, H.-M. | |
dc.contributor.author | Whiteman, M. | |
dc.contributor.author | Huang, C. | |
dc.date.accessioned | 2014-11-26T07:45:17Z | |
dc.date.available | 2014-11-26T07:45:17Z | |
dc.date.issued | 2006-11-20 | |
dc.identifier.citation | Song, L., Li, J., Zhang, D., Liu, Z.-G., Ye, J., Zhan, Q., Shen, H.-M., Whiteman, M., Huang, C. (2006-11-20). IKKβ programs to turn on the GADD45α-MKK4-JNK apoptotic cascade specifically via p50 NF-κB in arsenite response. Journal of Cell Biology 175 (4) : 607-617. ScholarBank@NUS Repository. https://doi.org/10.1083/jcb.200602149 | |
dc.identifier.issn | 00219525 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/109391 | |
dc.description.abstract | Cross talk between NF-κB and c-Jun N-terminal kinases (JNKs) has been implicated in the cell life and death decision under various stresses. Functional suppression of JNK activation by NF-κB has recently been proposed as a key cellular survival mechanism and contributes to cancer cells escaping from apoptosis. We provide a novel scenario of the proapoptotic role of IκB kinase β (IKKβ)-NF-κB, which can act as the activator of the JNK pathway through the induction of GADD45α for triggering MKK4/JNK activation, in response to the stimulation of arsenite, a cancer therapeutic reagent. This effect of IKKβ-NF-κB is dependent on p50 but not the p65/relA NF-κB subunit, which can increase the stability of GADD45α protein through suppressing its ubiquitination and proteasome-dependent degradation. IKKβ-NF-κB can therefore either activate or suppress the JNK cascade and consequently mediate pro- or antiapoptotic effects, depending on the manner of its induction. Furthermore, the NF-κB p50 subunit can exert a novel regulatory function on protein modification independent of the classical NF-κB transcriptional activity. © The Rockefeller University Press. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1083/jcb.200602149 | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | COMMUNITY,OCCUPATIONAL & FAMILY MEDICINE | |
dc.description.doi | 10.1083/jcb.200602149 | |
dc.description.sourcetitle | Journal of Cell Biology | |
dc.description.volume | 175 | |
dc.description.issue | 4 | |
dc.description.page | 607-617 | |
dc.description.coden | JCLBA | |
dc.identifier.isiut | 000242291200011 | |
Appears in Collections: | Staff Publications |
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