Please use this identifier to cite or link to this item: https://doi.org/10.1083/jcb.200602149
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dc.titleIKKβ programs to turn on the GADD45α-MKK4-JNK apoptotic cascade specifically via p50 NF-κB in arsenite response
dc.contributor.authorSong, L.
dc.contributor.authorLi, J.
dc.contributor.authorZhang, D.
dc.contributor.authorLiu, Z.-G.
dc.contributor.authorYe, J.
dc.contributor.authorZhan, Q.
dc.contributor.authorShen, H.-M.
dc.contributor.authorWhiteman, M.
dc.contributor.authorHuang, C.
dc.date.accessioned2014-11-26T07:45:17Z
dc.date.available2014-11-26T07:45:17Z
dc.date.issued2006-11-20
dc.identifier.citationSong, L., Li, J., Zhang, D., Liu, Z.-G., Ye, J., Zhan, Q., Shen, H.-M., Whiteman, M., Huang, C. (2006-11-20). IKKβ programs to turn on the GADD45α-MKK4-JNK apoptotic cascade specifically via p50 NF-κB in arsenite response. Journal of Cell Biology 175 (4) : 607-617. ScholarBank@NUS Repository. https://doi.org/10.1083/jcb.200602149
dc.identifier.issn00219525
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/109391
dc.description.abstractCross talk between NF-κB and c-Jun N-terminal kinases (JNKs) has been implicated in the cell life and death decision under various stresses. Functional suppression of JNK activation by NF-κB has recently been proposed as a key cellular survival mechanism and contributes to cancer cells escaping from apoptosis. We provide a novel scenario of the proapoptotic role of IκB kinase β (IKKβ)-NF-κB, which can act as the activator of the JNK pathway through the induction of GADD45α for triggering MKK4/JNK activation, in response to the stimulation of arsenite, a cancer therapeutic reagent. This effect of IKKβ-NF-κB is dependent on p50 but not the p65/relA NF-κB subunit, which can increase the stability of GADD45α protein through suppressing its ubiquitination and proteasome-dependent degradation. IKKβ-NF-κB can therefore either activate or suppress the JNK cascade and consequently mediate pro- or antiapoptotic effects, depending on the manner of its induction. Furthermore, the NF-κB p50 subunit can exert a novel regulatory function on protein modification independent of the classical NF-κB transcriptional activity. © The Rockefeller University Press.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1083/jcb.200602149
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentCOMMUNITY,OCCUPATIONAL & FAMILY MEDICINE
dc.description.doi10.1083/jcb.200602149
dc.description.sourcetitleJournal of Cell Biology
dc.description.volume175
dc.description.issue4
dc.description.page607-617
dc.description.codenJCLBA
dc.identifier.isiut000242291200011
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