Please use this identifier to cite or link to this item: https://doi.org/10.1007/s11882-012-0328-6
Title: Gene expression signatures: A new approach to understanding the pathophysiology of chronic rhinosinusitis
Authors: Li, C. 
Shi, L.
Yan, Y.
Gordon, B.R.
Gordon, W.M.
Wang, D.-Y.
Keywords: Chronic rhinosinusitis (CRS)
Environmental factors
Gene expression signatures
Glucocorticosteroids
Host defense mechanisms
Inflammation
Nasal epithelium
Nasal polyps
Pathophysiology
Regulatory T cells (T-reg)
Remodeling
Issue Date: Apr-2013
Citation: Li, C., Shi, L., Yan, Y., Gordon, B.R., Gordon, W.M., Wang, D.-Y. (2013-04). Gene expression signatures: A new approach to understanding the pathophysiology of chronic rhinosinusitis. Current Allergy and Asthma Reports 13 (2) : 209-217. ScholarBank@NUS Repository. https://doi.org/10.1007/s11882-012-0328-6
Abstract: Chronic rhinosinusitis (CRS) is a complex inflammatory disease with variable disease manifestation. Though external risk factors are associated with development and/or persistence of CRS, the host mucosal response is also important, as nasal epithelium acts as a physical and immune barrier. Under inflammatory stress, the nasal epithelium can undergo injury, followed by a rapid remodeling response ranging from epithelial hyperplasia, to goblet-cell metaplasia, to denudation, loss of cilia, fibrosis, and basement membrane thickening. Identification of gene expression signatures and molecular pathways in CRS pathogenesis have now begun to contribute significantly to a better understanding of the genetic and molecular alterations underlying CRS development and progression. Genetic studies are especially illuminating when multiple gene variants synergize within a permissive environmental context, and are expected to guide development of more effective therapeutic targets for CRS treatment. © 2012 Springer Science+Business Media New York.
Source Title: Current Allergy and Asthma Reports
URI: http://scholarbank.nus.edu.sg/handle/10635/109360
ISSN: 15297322
DOI: 10.1007/s11882-012-0328-6
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

20
checked on Nov 27, 2020

WEB OF SCIENCETM
Citations

17
checked on Nov 27, 2020

Page view(s)

96
checked on Nov 28, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.