Engagement of the small gtpase rab31 protein and its effector, early endosome antigen 1, is important for trafficking of the ligand-bound epidermal growth factor receptor from the early to the late endosome

Abstract

Background: Rab31 is a member of the Rab5 subfamily of Rab GTPases. Results: Manipulation of Rab31 and interacting partners affects trafficking of the EGF receptor (EGFR) to the late endosome. Conclusion: Rab31, with its regulator and effector, plays an important role in the trafficking of the EGFR from the early to the late endosome. Significance: Evidence is provided for Rab31 being a key regulator of endocytic traffic of the EGFR. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.