Please use this identifier to cite or link to this item:
|Title:||A study of HER2 gene amplification and protein expression in gastric cancer||Authors:||Yan, B.
|Issue Date:||Sep-2010||Citation:||Yan, B., Yau, E.X., Omar, S.S.B., Ong, C.W., Pang, B., Yeoh, K.G., Salto-Tellez, M. (2010-09). A study of HER2 gene amplification and protein expression in gastric cancer. Journal of Clinical Pathology 63 (9) : 839-842. ScholarBank@NUS Repository. https://doi.org/10.1136/jcp.2010.076570||Abstract:||Background: Gastric cancer is a leading cause of cancer-related mortality, and current treatment outcomes for advanced disease remain poor. HER2 has been identified as a potential candidate for targeted therapy in gastric cancers displaying HER2 gene amplification and protein overexpression. Aims: To study the prevalence rate of HER2 gene amplification/overexpression in a local population, and determine the concordance rate between the various modalities. Methods: 128 gastric cancer samples were analysed by fluorescence (FISH) and chromogenic (CISH) in situ hybridisation and immunohistochemistry (IHC). The relation between HER2 status and various clinicopathological parameters was also analysed. Results: 11.7% (15/128) and 9.4% (12/128) of gastric cancers displayed HER2 gene amplification and protein overexpression (score 3+), respectively, with a perfect correlation between the FISH and CISH analyses. There was also a significant inverse correlation between overall survival and HER2 protein overexpression in intestinal-type gastric carcinomas (p||Source Title:||Journal of Clinical Pathology||URI:||http://scholarbank.nus.edu.sg/handle/10635/109151||ISSN:||00219746||DOI:||10.1136/jcp.2010.076570|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jun 16, 2021
WEB OF SCIENCETM
checked on Jun 7, 2021
checked on Jun 19, 2021
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.