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Title: A study of HER2 gene amplification and protein expression in gastric cancer
Authors: Yan, B.
Yau, E.X. 
Omar, S.S.B.
Ong, C.W. 
Pang, B.
Yeoh, K.G.
Salto-Tellez, M. 
Issue Date: Sep-2010
Citation: Yan, B., Yau, E.X., Omar, S.S.B., Ong, C.W., Pang, B., Yeoh, K.G., Salto-Tellez, M. (2010-09). A study of HER2 gene amplification and protein expression in gastric cancer. Journal of Clinical Pathology 63 (9) : 839-842. ScholarBank@NUS Repository.
Abstract: Background: Gastric cancer is a leading cause of cancer-related mortality, and current treatment outcomes for advanced disease remain poor. HER2 has been identified as a potential candidate for targeted therapy in gastric cancers displaying HER2 gene amplification and protein overexpression. Aims: To study the prevalence rate of HER2 gene amplification/overexpression in a local population, and determine the concordance rate between the various modalities. Methods: 128 gastric cancer samples were analysed by fluorescence (FISH) and chromogenic (CISH) in situ hybridisation and immunohistochemistry (IHC). The relation between HER2 status and various clinicopathological parameters was also analysed. Results: 11.7% (15/128) and 9.4% (12/128) of gastric cancers displayed HER2 gene amplification and protein overexpression (score 3+), respectively, with a perfect correlation between the FISH and CISH analyses. There was also a significant inverse correlation between overall survival and HER2 protein overexpression in intestinal-type gastric carcinomas (p
Source Title: Journal of Clinical Pathology
ISSN: 00219746
DOI: 10.1136/jcp.2010.076570
Appears in Collections:Staff Publications

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