Please use this identifier to cite or link to this item: https://doi.org/10.1002/ijc.26206
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dc.titleBreast cancer prognosis is inherited independently of patient, tumor and treatment characteristics
dc.contributor.authorVerkooijen, H.M.
dc.contributor.authorHartman, M.
dc.contributor.authorUsel, M.
dc.contributor.authorBenhamou, S.
dc.contributor.authorNeyroud-Caspar, I.
dc.contributor.authorCzene, K.
dc.contributor.authorVlastos, G.
dc.contributor.authorChappuis, P.O.
dc.contributor.authorBouchardy, C.
dc.contributor.authorRapiti, E.
dc.date.accessioned2014-11-26T05:02:31Z
dc.date.available2014-11-26T05:02:31Z
dc.date.issued2012-05-01
dc.identifier.citationVerkooijen, H.M., Hartman, M., Usel, M., Benhamou, S., Neyroud-Caspar, I., Czene, K., Vlastos, G., Chappuis, P.O., Bouchardy, C., Rapiti, E. (2012-05-01). Breast cancer prognosis is inherited independently of patient, tumor and treatment characteristics. International Journal of Cancer 130 (9) : 2103-2110. ScholarBank@NUS Repository. https://doi.org/10.1002/ijc.26206
dc.identifier.issn00207136
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/108885
dc.description.abstractPopulation-based studies have shown a concordance of breast cancer survival among first-degree relatives (FDRs), suggesting a heritable component. Reasons for such heritability remain to be elucidated. We aimed to determine whether association of breast cancer survival among FDRs is linked to shared patient and tumor characteristics or type of treatment. At the population-based Geneva Breast Cancer Registry, we identified 162 FDR pairs diagnosed with breast cancer. We categorized FDRs into poor, medium and good familial survival risk groups according to breast cancer-specific survival of their proband (mother or sister). We compared patient, tumor and treatment characteristics between categories and calculated standardized mortality ratios (SMRs) and adjusted disease-specific mortality for each group. Breast cancer patients in the poor familial survival risk group were more likely to be diagnosed at later stages than those in the good familial survival risk group. Similarly, they had higher SMRs than those in the medium and good survival risk groups (18.7, 95% confidence interval [CI]: 9.4-33.5 vs. 16.5, 95% CI: 7.5-31.3 and 9.4, 95% CI: 3.4-20.4, respectively). After adjustment for patient and tumor characteristics and type of treatment, women in the poor familial survival risk group were almost five times more likely to die of breast cancer than those in the good familial survival risk group (adjusted hazard ratio 4.8, 95% CI: 1.4-16.4). Our study shows that breast cancer prognosis clusters within families and suggests that the hereditary component is independent of patient and tumor characteristics and type of treatment. © 2011 UICC.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/ijc.26206
dc.sourceScopus
dc.subjectbreast cancer
dc.subjectepidemiology
dc.subjectheritability
dc.subjectprognosis
dc.typeArticle
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.doi10.1002/ijc.26206
dc.description.sourcetitleInternational Journal of Cancer
dc.description.volume130
dc.description.issue9
dc.description.page2103-2110
dc.description.codenIJCNA
dc.identifier.isiut000300693100015
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