Please use this identifier to cite or link to this item: https://doi.org/10.2337/db13-0129
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dc.titleGenetic variation in cdh13 is associated with lower plasma adiponectin levels but greater adiponectin sensitivity in east asian populations
dc.contributor.authorGao, H.
dc.contributor.authorKim, Y.-M.
dc.contributor.authorChen, P.
dc.contributor.authorIgase, M.
dc.contributor.authorKawamoto, R.
dc.contributor.authorKim, M.K.
dc.contributor.authorKohara, K.
dc.contributor.authorLee, J.
dc.contributor.authorMiki, T.
dc.contributor.authorOng, R.T.-H.
dc.contributor.authorOnuma, H.
dc.contributor.authorOsawa, H.
dc.contributor.authorSim, X.
dc.contributor.authorTeo, Y.Y.
dc.contributor.authorTabara, Y.
dc.contributor.authorTai, E.S.
dc.contributor.authorVan Dam, R.M.
dc.date.accessioned2014-11-26T02:12:27Z
dc.date.available2014-11-26T02:12:27Z
dc.date.issued2013-12
dc.identifier.citationGao, H., Kim, Y.-M., Chen, P., Igase, M., Kawamoto, R., Kim, M.K., Kohara, K., Lee, J., Miki, T., Ong, R.T.-H., Onuma, H., Osawa, H., Sim, X., Teo, Y.Y., Tabara, Y., Tai, E.S., Van Dam, R.M. (2013-12). Genetic variation in cdh13 is associated with lower plasma adiponectin levels but greater adiponectin sensitivity in east asian populations. Diabetes 62 (12) : 4277-4283. ScholarBank@NUS Repository. https://doi.org/10.2337/db13-0129
dc.identifier.issn00121797
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/108758
dc.description.abstractVariants in the CDH13 gene have been identified as determinants of blood levels of adiponectin, an insulin-sensitizing adipokine. However, their association with other metabolic risk factors remains unclear. We examined variants at CDH13 in relation to total and high-molecular-weight (HMW) adiponectin using data from a genome-wide association study performed in 2,434 Singaporean Chinese with replication in up to 3,290 Japanese and 1,610 Koreans. The top signal rs4783244 in CDH13 showed strong associations with total adiponectin (standardized b [b] = 20.34, 95% CI 20.38 to 20.30, P = 2.0 3 10270), HMW adiponectin (b = 20.40, 95% CI 20.43 to 20.36, P = 1.1 3 102117), and the HMW-to-total adiponectin ratio (b = 20.44, 95% CI 20.49 to 20.40, P = 3.2 3 10283). In the replication study, this single nucleotide polymorphism explained 4.1% of total and 6.5% of HMW adiponectin levels. No association was observed between rs4783244 and metabolic traits associated with insulin resistance before adjustment for HMW adiponectin levels. After adjustment for HMW adiponectin levels, the minor allele was associated with lower BMI (b = 20.15, 95% CI 20.19 to 20.11, P = 3.5 3 10214), homeostasis model assessment-insulin resistance index (b = 20.16, 95% CI 20.20 to 20.12, P = 9.2 3 10216), and triglycerides (b = 20.16, 95% CI 20.19 to 20.12, P = 1.3 3 10216) and with higher HDL (b = 0.16, 95% CI 0.12 to 0.19, P = 2.1 3 10217). CDH13 variants strongly influence plasma total and HMW adiponectin levels in East Asian populations but appear to alter adiponectin sensitivity, resulting in better metabolic health than expected based on circulating adiponectin levels. © 2013 by the American Diabetes Association.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.2337/db13-0129
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.contributor.departmentLIFE SCIENCES INSTITUTE
dc.description.doi10.2337/db13-0129
dc.description.sourcetitleDiabetes
dc.description.volume62
dc.description.issue12
dc.description.page4277-4283
dc.description.codenDIAEA
dc.identifier.isiut000333738500046
Appears in Collections:Staff Publications

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