Please use this identifier to cite or link to this item: https://doi.org/10.3346/jkms.2013.28.3.415
Title: Combined genome-wide linkage and association analyses of fasting glucose level in healthy twins and families of Korea
Authors: Suh, Y.J.
Kim, S.H.
Kim, S.H.
Park, J.
Lim, H.A.
Park, H.J.
Choi, H.
Ng, D. 
Lee, M.K.
Nam, M.
Keywords: Fasting glucose level
Genetic linkage
Genome-wide
PRKCB1
PTPRA
Issue Date: Mar-2013
Citation: Suh, Y.J., Kim, S.H., Kim, S.H., Park, J., Lim, H.A., Park, H.J., Choi, H., Ng, D., Lee, M.K., Nam, M. (2013-03). Combined genome-wide linkage and association analyses of fasting glucose level in healthy twins and families of Korea. Journal of Korean Medical Science 28 (3) : 415-423. ScholarBank@NUS Repository. https://doi.org/10.3346/jkms.2013.28.3.415
Abstract: This study was undertaken to identify genetic polymorphisms that are associated with the risk of an elevated fasting glucose (FG) level using genome-wide analyses. We explored a quantitative trait locus (QTL) for FG level in a genome-wide study from a Korean twinfamily cohort (the Healthy Twin Study) using a combined linkage and family-based association analysis approach. We investigated 1,754 individuals, which included 432 families and 219 pairs of monozygotic twins. Regions of chromosomes 2q23.3-2q31.1, 15q26.1-15q26.3, 16p12.1, and 20p13-20p12.2, were found to show evidence of linkage with FG level, and several markers in these regions were found to be significantly associated with FG level using family-based or general association tests. In particular, a single-nucleotide polymorphism (rs6138953) on the PTPRA gene in the 20p13 region (combined P = 1.8 × 10-6) was found to be associated with FG level, and the PRKCB1 gene (in 16p12.1) to be possibly associated with FG level. In conclusion, multiple regions of chromosomes 2q23.3-2q31.1, 15q26.1-15q26.3, 16p12.1, and 20p13-20p12.2 are associated with FG level in our Korean twin-family cohort. The combined approach of genome-wide linkage and family-based association analysis is useful to identify novel or known genetic regions concerning FG level in a family cohort study. © 2013 The Korean Academy of Medical Sciences.
Source Title: Journal of Korean Medical Science
URI: http://scholarbank.nus.edu.sg/handle/10635/108730
ISSN: 10118934
DOI: 10.3346/jkms.2013.28.3.415
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