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|Title:||Combined genome-wide linkage and association analyses of fasting glucose level in healthy twins and families of Korea||Authors:||Suh, Y.J.
|Keywords:||Fasting glucose level
|Issue Date:||Mar-2013||Citation:||Suh, Y.J., Kim, S.H., Kim, S.H., Park, J., Lim, H.A., Park, H.J., Choi, H., Ng, D., Lee, M.K., Nam, M. (2013-03). Combined genome-wide linkage and association analyses of fasting glucose level in healthy twins and families of Korea. Journal of Korean Medical Science 28 (3) : 415-423. ScholarBank@NUS Repository. https://doi.org/10.3346/jkms.2013.28.3.415||Abstract:||This study was undertaken to identify genetic polymorphisms that are associated with the risk of an elevated fasting glucose (FG) level using genome-wide analyses. We explored a quantitative trait locus (QTL) for FG level in a genome-wide study from a Korean twinfamily cohort (the Healthy Twin Study) using a combined linkage and family-based association analysis approach. We investigated 1,754 individuals, which included 432 families and 219 pairs of monozygotic twins. Regions of chromosomes 2q23.3-2q31.1, 15q26.1-15q26.3, 16p12.1, and 20p13-20p12.2, were found to show evidence of linkage with FG level, and several markers in these regions were found to be significantly associated with FG level using family-based or general association tests. In particular, a single-nucleotide polymorphism (rs6138953) on the PTPRA gene in the 20p13 region (combined P = 1.8 × 10-6) was found to be associated with FG level, and the PRKCB1 gene (in 16p12.1) to be possibly associated with FG level. In conclusion, multiple regions of chromosomes 2q23.3-2q31.1, 15q26.1-15q26.3, 16p12.1, and 20p13-20p12.2 are associated with FG level in our Korean twin-family cohort. The combined approach of genome-wide linkage and family-based association analysis is useful to identify novel or known genetic regions concerning FG level in a family cohort study. © 2013 The Korean Academy of Medical Sciences.||Source Title:||Journal of Korean Medical Science||URI:||http://scholarbank.nus.edu.sg/handle/10635/108730||ISSN:||10118934||DOI:||10.3346/jkms.2013.28.3.415|
|Appears in Collections:||Staff Publications|
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