1. ScholarBank@NUS
  2. 1. Staff
  3. Staff Publications
Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.febslet.2013.04.036
DC FieldValue
dc.titleThe Evi5 family in cellular physiology and pathology
dc.contributor.authorLim, Y.S.
dc.contributor.authorTang, B.L.
dc.date.accessioned2014-11-25T09:49:08Z
dc.date.available2014-11-25T09:49:08Z
dc.date.issued2013-06-19
dc.identifier.citationLim, Y.S., Tang, B.L. (2013-06-19). The Evi5 family in cellular physiology and pathology. FEBS Letters 587 (12) : 1703-1710. ScholarBank@NUS Repository. https://doi.org/10.1016/j.febslet.2013.04.036
dc.identifier.issn00145793
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/108695
dc.description.abstractThe Ecotropic viral integration site 5 (Evi5) and Evi5-like (Evi5L) belong to a small subfamily of the Tre-2/Bub2/Cdc16 (TBC) domain-containing proteins with enigmatically divergent roles as modulators of cell cycle progression, cytokinesis, and cellular membrane traffic. First recognized as a potential oncogene and a cell cycle regulator, Evi5 acts as a GTPase Activating Protein (GAP) for Rab11 in cytokinesis. On the other hand, its homologue Evi5L has Rab-GAP activity towards Rab10 as well as Rab23, and has been implicated in primary cilia formation. Recent genetic susceptibility analysis points to Evi5 as an important factor in susceptibility to multiple sclerosis. We discuss below the myriad of cellular functions exhibited by the Evi5 family members, and their associations with disease conditions. © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.febslet.2013.04.036
dc.sourceScopus
dc.subjectActivating
dc.subjectCell cycle
dc.subjectEvi5 GTPase
dc.subjectProtein (GAP)
dc.subjectRab
dc.typeReview
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.1016/j.febslet.2013.04.036
dc.description.sourcetitleFEBS Letters
dc.description.volume587
dc.description.issue12
dc.description.page1703-1710
dc.description.codenFEBLA
dc.identifier.isiut000320427400002
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.