Please use this identifier to cite or link to this item: https://doi.org/10.1586/14789450.2013.858022
DC FieldValue
dc.titleRecent advances in mass spectrometry: Data independent analysis and hyper reaction monitoring
dc.contributor.authorLaw, K.P.
dc.contributor.authorLim, Y.P.
dc.date.accessioned2014-11-25T09:49:00Z
dc.date.available2014-11-25T09:49:00Z
dc.date.issued2013
dc.identifier.citationLaw, K.P., Lim, Y.P. (2013). Recent advances in mass spectrometry: Data independent analysis and hyper reaction monitoring. Expert Review of Proteomics 10 (6) : 551-566. ScholarBank@NUS Repository. https://doi.org/10.1586/14789450.2013.858022
dc.identifier.issn14789450
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/108682
dc.description.abstractNew mass spectrometry (MS) methods, collectively known as data independent analysis and hyper reaction monitoring, have recently emerged. These methods hold promises to address the shortcomings of data-dependent analysis and selected reaction monitoring (SRM) employed in shotgun and targeted proteomics, respectively. They allow MS analyses of all species in a complex sample indiscriminately, or permit SRM-like experiments conducted with full high-resolution product ion spectra, potentially leading to higher sequence coverage or analytical selectivity. These methods include MSE, all-ion fragmentation, Fourier transform-all reaction monitoring, SWATH Acquisition, multiplexed MS/MS, pseudo-SRM (pSRM) and parallel reaction monitoring (PRM). In this review, the strengths and pitfalls of these methods are discussed and illustrated with examples. In essence, the suitability of the use of each method is contingent on the biological questions posed. Although these methods do not fundamentally change the shape of proteomics, they are useful additional tools that should expedite biological discoveries. © 2013 Informa UK, Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1586/14789450.2013.858022
dc.sourceScopus
dc.subjectAif
dc.subjectDia
dc.subjectFt-Arm
dc.subjectHrm
dc.subjectMrmhr
dc.subjectMse
dc.subjectMsx
dc.subjectPrm
dc.subjectPsrm
dc.subjectSAWTH-MS
dc.typeReview
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.1586/14789450.2013.858022
dc.description.sourcetitleExpert Review of Proteomics
dc.description.volume10
dc.description.issue6
dc.description.page551-566
dc.identifier.isiut000326707600009
Appears in Collections:Staff Publications

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