Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.eplepsyres.2008.07.014
DC FieldValue
dc.titlemGluR5-PLCβ4-PKCβ2/PKCγ pathways in hippocampal CA1 pyramidal neurons in pilocarpine model of status epilepticus in mGluR5+/+ mice
dc.contributor.authorLiu, J.X.
dc.contributor.authorTang, Y.C.
dc.contributor.authorLiu, Y.
dc.contributor.authorTang, F.R.
dc.date.accessioned2014-11-25T09:46:30Z
dc.date.available2014-11-25T09:46:30Z
dc.date.issued2008-12
dc.identifier.citationLiu, J.X., Tang, Y.C., Liu, Y., Tang, F.R. (2008-12). mGluR5-PLCβ4-PKCβ2/PKCγ pathways in hippocampal CA1 pyramidal neurons in pilocarpine model of status epilepticus in mGluR5+/+ mice. Epilepsy Research 82 (2-3) : 111-123. ScholarBank@NUS Repository. https://doi.org/10.1016/j.eplepsyres.2008.07.014
dc.identifier.issn09201211
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/108465
dc.description.abstractWhile it is generally accepted that phospholipase C (PLC) and protein kinase C (PKC) are down-stream proteins involved in metabotropic glutamate receptor 5 (mGluR5)-related signal transduction, we still do not know which subtype of PLC or PKC is specifically regulated after mGluR5 activation. In the present study in mGluR5 wild-type (mGluR5+/+) mice, we showed induced PKCβ2 or PKCγ expression at the border between the stratum oriens and alveus (O/A border) at 2 h during pilocarpine induced status epilepticus (SE), and in the stratum pyramidale in CA1 area at 1 day after pilocarpine induced SE; at 1 day, induced expression of PLCβ4 in the stratum pyramidale of CA1 area was observed. Furthermore, double labeling revealed the co-localization of induced PKCβ2 or PKCγ with mGluR5 or with induced PLCβ4 in the stratum pyramidale of CA1 area. These induced expression, however, were not found in mGluR5 mutant (mGluR5-/-) mice. It suggests that induced PLCβ4-PKCβ2/PKCγ at 1 day after pilocarpine induced SE in pyramidal neurons or PKCβ2 or PKCγ in interneurons at O/A border at 2 h during pilocarpine induced SE may be specifically linked to the activation of mGluR5. When compared to mGluR5+/+ mice, significant shorter latency (from pilocarpine injection to the occurrence of status epilepticus) and maintenance period (from beginning to the end of status epilepticus) for status epilepticus in mGluR5-/- mice were also demonstrated. It is possible that mGluR5 may play a negative role in initiation of status epilepticus by interacting with muscarinic acetylcholine receptor in mGluR5+/+ mice. © 2008 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.eplepsyres.2008.07.014
dc.sourceScopus
dc.subjectHippocampus
dc.subjectMetabotropic glutamate receptor 5
dc.subjectPilocarpine
dc.subjectProtein kinase C
dc.subjectStatus epilepticus
dc.typeArticle
dc.contributor.departmentANATOMY
dc.description.doi10.1016/j.eplepsyres.2008.07.014
dc.description.sourcetitleEpilepsy Research
dc.description.volume82
dc.description.issue2-3
dc.description.page111-123
dc.description.codenEPIRE
dc.identifier.isiut000261941600001
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

16
checked on Apr 4, 2020

WEB OF SCIENCETM
Citations

14
checked on Mar 19, 2020

Page view(s)

61
checked on Mar 28, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.