Please use this identifier to cite or link to this item: https://doi.org/10.2741/2319
Title: Mammalian specific mouse genes are evolving faster than mouse genes conserved across other eukaryotic lineages
Authors: Chaturvedi, I.
Hlaing, M.M.
Sing, L.C.
Sakharkar, K.R. 
Sakharkar, M.K.
Keywords: ENC
Evolution
Evolutionary rate
Human
Lineage
Mouse
Selection
Issue Date: 1-May-2007
Citation: Chaturvedi, I., Hlaing, M.M., Sing, L.C., Sakharkar, K.R., Sakharkar, M.K. (2007-05-01). Mammalian specific mouse genes are evolving faster than mouse genes conserved across other eukaryotic lineages. Frontiers in Bioscience 12 (9) : 3367-3376. ScholarBank@NUS Repository. https://doi.org/10.2741/2319
Abstract: Positive selection is usually considered in the context of a higher rate of substitutions in nonsynonymous as compared to synonymous sites in complete coding sequences of genes or individual positions. We show that genes conserved in eukaryota, coelomata, and bilateria, that is, proteins that arose earlier in evolution as compared to mammalia specific genes evolve slowly and are subjected to negative selection. This finding supports the notion that evolutionary rates progressively diminish with the age of a gene. The data suggests that in both introncontaining and intronless genes synonymous sites may be subject to some degree of selection that is indicative of a relative acceleration of amino-acid substitution, which could be due to a relaxation of functional constraints and/or directional selection.
Source Title: Frontiers in Bioscience
URI: http://scholarbank.nus.edu.sg/handle/10635/108457
ISSN: 10939946
DOI: 10.2741/2319
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