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https://doi.org/10.1002/mds.22277
Title: | Hyperglycemic choreoathetosis: Role of the putamen in pathogenesis | Authors: | Kandiah, N. Tan, K. Lim, C.C.T. Venketasubramanian, N. |
Keywords: | Choreoathetosis Hyperglycemia Hyperviscosity Striatum;putamen |
Issue Date: | 30-Apr-2009 | Citation: | Kandiah, N., Tan, K., Lim, C.C.T., Venketasubramanian, N. (2009-04-30). Hyperglycemic choreoathetosis: Role of the putamen in pathogenesis. Movement Disorders 24 (6) : 915-919. ScholarBank@NUS Repository. https://doi.org/10.1002/mds.22277 | Abstract: | Hyperglycemic choreoathetosis (HC) is an uncommon syndrome often associated with hyperintensity of the basal ganglia on MRI. We performed a retrospective review of cases with HC to characterize the clinical, biochemical, and neuroimaging (CT, MRI, and MR spectroscopy) findings and to propose a mechanism for this syndrome. Seven HC patients with a mean age of 75.1 years, mean blood glucose of 27.4 mmol/L, and mean plasma osmolarity of 313.4 mmol/L were studied. All had MR-T1 hyperintensity of the putamen on the side contralateral to the choreoathetosis. Two patients had additional hyperintensity of the globus pallidus while one also had involvement of the caudate. On MR-T2, 2 patients showed hyperintensity, 2 isointensity, and 3 hypointensity in the putamen. MR spectroscopy showed elevated choline and reduced N-acetylaspartate; two patients also had elevated myoinositol levels. Our findings suggest that the putamen has a central role in HC, and MR spectroscopy supports neuronal dysfunction in the putamen. Biochemical and neuroimaging findings support hyperviscosity as the most plausible mechanism. © 2009 Movement Disorder Society. | Source Title: | Movement Disorders | URI: | http://scholarbank.nus.edu.sg/handle/10635/108408 | ISSN: | 08853185 | DOI: | 10.1002/mds.22277 |
Appears in Collections: | Staff Publications |
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