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Title: Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1
Authors: Khor, C.C. 
Chau, T.N.B.
Pang, J.
Davila, S.
Long, H.T.
Ong, R.T.H. 
Dunstan, S.J.
Wills, B.
Farrar, J.
Van Tram, T.
Gan, T.T.
Binh, N.T.N.
Tri, L.T.
Lien, L.B.
Tuan, N.M.
Tham, N.T.H.
Lanh, M.N.
Nguyet, N.M.
Hieu, N.T.
Van N Vinh Chau, N.
Thuy, T.T.
Tan, D.E.K.
Sakuntabhai, A.
Teo, Y.-Y. 
Hibberd, M.L. 
Simmons, C.P.
Issue Date: Nov-2011
Citation: Khor, C.C., Chau, T.N.B., Pang, J., Davila, S., Long, H.T., Ong, R.T.H., Dunstan, S.J., Wills, B., Farrar, J., Van Tram, T., Gan, T.T., Binh, N.T.N., Tri, L.T., Lien, L.B., Tuan, N.M., Tham, N.T.H., Lanh, M.N., Nguyet, N.M., Hieu, N.T., Van N Vinh Chau, N., Thuy, T.T., Tan, D.E.K., Sakuntabhai, A., Teo, Y.-Y., Hibberd, M.L., Simmons, C.P. (2011-11). Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1. Nature Genetics 43 (11) : 1139-1141. ScholarBank@NUS Repository.
Abstract: Hypovolemic shock (dengue shock syndrome (DSS)) is the most common life-threatening complication of dengue. We conducted a genome-wide association study of 2,008 pediatric cases treated for DSS and 2,018 controls from Vietnam. Replication of the most significantly associated markers was carried out in an independent Vietnamese sample of 1,737 cases and 2,934 controls. SNPs at two loci showed genome-wide significant association with DSS. We identified a susceptibility locus at MICB (major histocompatibility complex (MHC) class I polypeptide-related sequence B), which was within the broad MHC region on chromosome 6 but outside the class I and class II HLA loci (rs3132468, P meta = 4.41 × 10 -11, per-allele odds ratio (OR) = 1.34 (95% confidence interval: 1.23-1.46)). We identified associated variants within PLCE1 (phospholipase C, epsilon 1) on chromosome 10 (rs3765524, P meta = 3.08 × 10 -10, per-allele OR = 0.80 (95% confidence interval: 0.75-0.86)). We identify two loci associated with susceptibility to DSS in people with dengue, suggesting possible mechanisms for this severe complication of dengue. © 2011 Nature America, Inc. All rights reserved.
Source Title: Nature Genetics
ISSN: 10614036
DOI: 10.1038/ng.960
Appears in Collections:Staff Publications

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