1. ScholarBank@NUS
  2. 1. Staff
  3. Staff Publications
Please use this identifier to cite or link to this item: https://doi.org/10.1038/ng.981
DC FieldValue
dc.titleGenome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease
dc.contributor.authorKhor, C.C.
dc.contributor.authorDavila, S.
dc.contributor.authorBreunis, W.B.
dc.contributor.authorLee, Y.-C.
dc.contributor.authorShimizu, C.
dc.contributor.authorWright, V.J.
dc.contributor.authorYeung, R.S.M.
dc.contributor.authorTan, D.E.K.
dc.contributor.authorSim, K.S.
dc.contributor.authorWang, J.J.
dc.contributor.authorWong, T.Y.
dc.contributor.authorPang, J.
dc.contributor.authorMitchell, P.
dc.contributor.authorCimaz, R.
dc.contributor.authorDahdah, N.
dc.contributor.authorCheung, Y.-F.
dc.contributor.authorHuang, G.-Y.
dc.contributor.authorYang, W.
dc.contributor.authorPark, I.-S.
dc.contributor.authorLee, J.-K.
dc.contributor.authorWu, J.-Y.
dc.contributor.authorLevin, M.
dc.contributor.authorBurns, J.C.
dc.contributor.authorBurgner, D.
dc.contributor.authorKuijpers, T.W.
dc.contributor.authorHibberd, M.L.
dc.contributor.authorLau, Y.-L.
dc.contributor.authorZhang, J.
dc.contributor.authorMa, X.-J.
dc.contributor.authorLiu, F.
dc.contributor.authorWu, L.
dc.contributor.authorYoo, J.-J.
dc.contributor.authorHong, S.-J.
dc.contributor.authorKim, K.-J.
dc.contributor.authorKim, J.-J.
dc.contributor.authorPark, Y.-M.
dc.contributor.authorHong, Y.M.
dc.contributor.authorSohn, S.
dc.contributor.authorJang, G.Y.
dc.contributor.authorHa, K.-S.
dc.contributor.authorNam, H.-K.
dc.contributor.authorByeon, J.-H.
dc.contributor.authorYun, S.W.
dc.contributor.authorHan, M.K.
dc.contributor.authorLee, K.-Y.
dc.contributor.authorHwang, J.-Y.
dc.contributor.authorRhim, J.-W.
dc.contributor.authorSong, M.S.
dc.contributor.authorLee, H.-D.
dc.contributor.authorKim, D.S.
dc.contributor.authorLee, J.-M.
dc.contributor.authorChang, J.-S.
dc.contributor.authorTsai, F.-J.
dc.contributor.authorLiang, C.-D.
dc.contributor.authorChen, M.-R.
dc.contributor.authorChi, H.
dc.contributor.authorChiu, N.-C.
dc.contributor.authorHuang, F.-Y.
dc.contributor.authorChang, L.-Y.
dc.contributor.authorHuang, L.-M.
dc.contributor.authorKuo, H.-C.
dc.contributor.authorHuang, K.-P.
dc.contributor.authorLee, M.-L.
dc.contributor.authorHwang, B.
dc.contributor.authorHuang, Y.-C.
dc.contributor.authorLee, P.-C.
dc.contributor.authorOdam, M.
dc.contributor.authorChristiansen, F.T.
dc.contributor.authorWitt, C.
dc.contributor.authorGoldwater, P.
dc.contributor.authorCurtis, N.
dc.contributor.authorPalasanthiran, P.
dc.contributor.authorZiegler, J.
dc.contributor.authorNissen, M.
dc.contributor.authorNourse, C.
dc.contributor.authorKuipers, I.M.
dc.contributor.authorOttenkamp, J.J.
dc.contributor.authorGeissler, J.
dc.contributor.authorBiezeveld, M.
dc.contributor.authorTacke, C.
dc.contributor.authorFilippini, L.
dc.contributor.authorBrogan, P.
dc.contributor.authorKlein, N.
dc.contributor.authorShah, V.
dc.contributor.authorDillon, M.
dc.contributor.authorBooy, R.
dc.contributor.authorShingadia, D.
dc.contributor.authorBose, A.
dc.contributor.authorMukasa, T.
dc.contributor.authorTulloh, R.
dc.contributor.authorMichie, C.
dc.contributor.authorNewburger, J.W.
dc.contributor.authorBaker, A.L.
dc.contributor.authorRowley, A.H.
dc.contributor.authorShulman, S.T.
dc.contributor.authorMason, W.
dc.contributor.authorTakahashi, M.
dc.contributor.authorMelish, M.E.
dc.contributor.authorTremoulet, A.H.
dc.contributor.authorViswanathan, A.
dc.contributor.authorRochtchina, E.
dc.contributor.authorAttia, J.
dc.contributor.authorScott, R.
dc.contributor.authorHolliday, E.
dc.contributor.authorHarrap, S.
dc.date.accessioned2014-11-25T09:45:36Z
dc.date.available2014-11-25T09:45:36Z
dc.date.issued2011-12
dc.identifier.citationKhor, C.C., Davila, S., Breunis, W.B., Lee, Y.-C., Shimizu, C., Wright, V.J., Yeung, R.S.M., Tan, D.E.K., Sim, K.S., Wang, J.J., Wong, T.Y., Pang, J., Mitchell, P., Cimaz, R., Dahdah, N., Cheung, Y.-F., Huang, G.-Y., Yang, W., Park, I.-S., Lee, J.-K., Wu, J.-Y., Levin, M., Burns, J.C., Burgner, D., Kuijpers, T.W., Hibberd, M.L., Lau, Y.-L., Zhang, J., Ma, X.-J., Liu, F., Wu, L., Yoo, J.-J., Hong, S.-J., Kim, K.-J., Kim, J.-J., Park, Y.-M., Hong, Y.M., Sohn, S., Jang, G.Y., Ha, K.-S., Nam, H.-K., Byeon, J.-H., Yun, S.W., Han, M.K., Lee, K.-Y., Hwang, J.-Y., Rhim, J.-W., Song, M.S., Lee, H.-D., Kim, D.S., Lee, J.-M., Chang, J.-S., Tsai, F.-J., Liang, C.-D., Chen, M.-R., Chi, H., Chiu, N.-C., Huang, F.-Y., Chang, L.-Y., Huang, L.-M., Kuo, H.-C., Huang, K.-P., Lee, M.-L., Hwang, B., Huang, Y.-C., Lee, P.-C., Odam, M., Christiansen, F.T., Witt, C., Goldwater, P., Curtis, N., Palasanthiran, P., Ziegler, J., Nissen, M., Nourse, C., Kuipers, I.M., Ottenkamp, J.J., Geissler, J., Biezeveld, M., Tacke, C., Filippini, L., Brogan, P., Klein, N., Shah, V., Dillon, M., Booy, R., Shingadia, D., Bose, A., Mukasa, T., Tulloh, R., Michie, C., Newburger, J.W., Baker, A.L., Rowley, A.H., Shulman, S.T., Mason, W., Takahashi, M., Melish, M.E., Tremoulet, A.H., Viswanathan, A., Rochtchina, E., Attia, J., Scott, R., Holliday, E., Harrap, S. (2011-12). Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. Nature Genetics 43 (12) : 1241-1246. ScholarBank@NUS Repository. https://doi.org/10.1038/ng.981
dc.identifier.issn10614036
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/108390
dc.description.abstractKawasaki disease is a systemic vasculitis of unknown etiology, with clinical observations suggesting a substantial genetic contribution to disease susceptibility. We conducted a genome-wide association study and replication analysis in 2,173 individuals with Kawasaki disease and 9,383 controls from five independent sample collections. Two loci exceeded the formal threshold for genome-wide significance. The first locus is a functional polymorphism in the IgG receptor gene FCGR2A (encoding an H131R substitution) (rs1801274; P = 7.35 × 10 -11, odds ratio (OR) = 1.32), with the A allele (coding for histadine) conferring elevated disease risk. The second locus is at 19q13, (P = 2.51 × 10 -9, OR = 1.42 for the rs2233152 SNP near MIA and RAB4B; P = 1.68 × 10 -12, OR = 1.52 for rs28493229 in ITPKC), which confirms previous findings. The involvement of the FCGR2A locus may have implications for understanding immune activation in Kawasaki disease pathogenesis and the mechanism of response to intravenous immunoglobulin, the only proven therapy for this disease. © 2011 Nature America, Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1038/ng.981
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentEPIDEMIOLOGY & PUBLIC HEALTH
dc.contributor.departmentCENTRE FOR MOLECULAR EPIDEMIOLOGY
dc.contributor.departmentOPHTHALMOLOGY
dc.description.doi10.1038/ng.981
dc.description.sourcetitleNature Genetics
dc.description.volume43
dc.description.issue12
dc.description.page1241-1246
dc.description.codenNGENE
dc.identifier.isiut000297931400020
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.