Please use this identifier to cite or link to this item: https://doi.org/10.1002/mas.20316
Title: Enhancement of the capabilities of liquid chromatography-mass spectrometry with derivatization: General principles and applications
Authors: Xu, F. 
Li, Z.
Liu, Y.
Zhang, Z.
Ong, C.N. 
Keywords: Biomedical analysis
Derivatization
Environmental analysis
Food-safety assessment
Liquid chromatography
Mass spectrometry
Metabolomics
Pharmaceutical analysis
Issue Date: Nov-2011
Citation: Xu, F., Li, Z., Liu, Y., Zhang, Z., Ong, C.N. (2011-11). Enhancement of the capabilities of liquid chromatography-mass spectrometry with derivatization: General principles and applications. Mass Spectrometry Reviews 30 (6) : 1143-1172. ScholarBank@NUS Repository. https://doi.org/10.1002/mas.20316
Abstract: The integration of liquid chromatography-mass spectrometry (LC-MS) with derivatization is a relatively new and unique strategy that could add value and could enhance the capabilities of LC-MS-based technologies. The derivatization process could be carried out in various analytical steps, for example, sampling, storage, sample preparation, HPLC separation, and MS detection. This review presents an overview of derivatization-based LC-MS strategy over the past 10 years and covers both the general principles and applications in the fields of pharmaceutical and biomedical analysis, biomarker and metabolomic research, environmental analysis, and foodsafety evaluation. The underlying mechanisms and theories for derivative reagent selection are summarized and highlighted to guide future studies. © 2011 Wiley Periodicals, Inc.
Source Title: Mass Spectrometry Reviews
URI: http://scholarbank.nus.edu.sg/handle/10635/108365
ISSN: 02777037
DOI: 10.1002/mas.20316
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