Please use this identifier to cite or link to this item: https://doi.org/10.1186/1471-2458-13-730
DC FieldValue
dc.titleCardio-metabolic risk factors and prehypertension in persons without diabetes, hypertension, and cardiovascular disease
dc.contributor.authorChiang, P.P.C.
dc.contributor.authorLamoureux, E.L.
dc.contributor.authorShankar, A.
dc.contributor.authorTai, E.S.
dc.contributor.authorWong, T.Y.
dc.contributor.authorSabanayagam, C.
dc.date.accessioned2014-11-25T09:44:11Z
dc.date.available2014-11-25T09:44:11Z
dc.date.issued2013
dc.identifier.citationChiang, P.P.C., Lamoureux, E.L., Shankar, A., Tai, E.S., Wong, T.Y., Sabanayagam, C. (2013). Cardio-metabolic risk factors and prehypertension in persons without diabetes, hypertension, and cardiovascular disease. BMC Public Health 13 (1) : -. ScholarBank@NUS Repository. https://doi.org/10.1186/1471-2458-13-730
dc.identifier.issn14712458
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/108283
dc.description.abstractBackground: Prehypertension has been shown to be an early risk factor of cardiovascular disease (CVD). We investigated the prevalence and pattern of cardiometabolic risk factors in prehypertension in three ethnic Asian populations in Singapore. Methods. We examined data from Chinese (n = 1177), Malay (n = 774), and Indian (n = 985) adults aged 40-80 years who participated in three independent population based studies conducted from 2004-2011 in Singapore who were free of diabetes, hypertension and previous CVD. Prehypertension was defined as systolic blood pressure (BP) 120-139 mm Hg or diastolic BP 80-89 mm Hg. Random blood glucose, glycated haemoglobin (HbA 1c), body mass index (BMI), triglycerides, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol were examined as indicators of adverse cardiometabolic profile. The association between metabolic variables and prehypertension was examined using logistic regression models adjusting for potential confounders. Results: The prevalence of prehypertension was 59.8% (Chinese), 68.9% (Malays) and 57.7% Indians. Higher levels of blood glucose, HbA1c and BMI were significantly associated with prehypertension in all three ethnic groups, odds ratio (95% confidence interval) of prehypertension in Chinese, Malays and Indians were: 1.42 (1.10, 1.83), 1.53 (1.05, 2.24), 1.49 (1.13, 1.98) for high-glucose; 3.50 (1.01, 12.18), 3.72 (1.29, 10.75), 2.79 (1.31, 5.94) for high-HbA1c; 1.86 (1.34, 2.56), 2.96 (2.10, 4.18), 1.68 (1.28, 2.20) for high-BMI. In addition, higher levels of LDL cholesterol in Chinese and higher levels of triglycerides were significantly associated with prehypertension. These associations persisted when metabolic variables were analysed as continuous variables. Conclusions: Higher levels of blood glucose, HbA1c and BMI were associated with prehypertension in all three ethnic groups in Singapore. Screening for prehypertension and lifestyle modifications could potentially reduce the burden of CVD in otherwise healthy Asian adults living in Singapore. © 2013 Chiang et al.; licensee BioMed Central Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1186/1471-2458-13-730
dc.sourceScopus
dc.subjectCardiometabolic
dc.subjectIndian
dc.subjectMetabolic syndrome
dc.subjectPrehypertension
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.contributor.departmentOPHTHALMOLOGY
dc.description.doi10.1186/1471-2458-13-730
dc.description.sourcetitleBMC Public Health
dc.description.volume13
dc.description.issue1
dc.description.page-
dc.identifier.isiut000323120300002
Appears in Collections:Staff Publications
Elements

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
2013-Cardio_metabolic_risk_factors_prehypertension-published.pdf196.96 kBAdobe PDF

OPEN

PublishedView/Download

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.