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Please use this identifier to cite or link to this item: https://doi.org/10.1038/ng.2352
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dc.titleMeta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations
dc.contributor.authorOkada, Y.
dc.contributor.authorSim, X.
dc.contributor.authorGo, M.J.
dc.contributor.authorWu, J.-Y.
dc.contributor.authorGu, D.
dc.contributor.authorTakeuchi, F.
dc.contributor.authorTakahashi, A.
dc.contributor.authorMaeda, S.
dc.contributor.authorTsunoda, T.
dc.contributor.authorChen, P.
dc.contributor.authorLim, S.-C.
dc.contributor.authorWong, T.-Y.
dc.contributor.authorLiu, J.
dc.contributor.authorYoung, T.L.
dc.contributor.authorAung, T.
dc.contributor.authorSeielstad, M.
dc.contributor.authorTeo, Y.-Y.
dc.contributor.authorKim, Y.J.
dc.contributor.authorLee, J.-Y.
dc.contributor.authorHan, B.-G.
dc.contributor.authorKang, D.
dc.contributor.authorChen, C.-H.
dc.contributor.authorTsai, F.-J.
dc.contributor.authorChang, L.-C.
dc.contributor.authorCathy Fann, S.-J.C.
dc.contributor.authorMei, H.
dc.contributor.authorRao, D.C.
dc.contributor.authorHixson, J.E.
dc.contributor.authorChen, S.
dc.contributor.authorKatsuya, T.
dc.contributor.authorIsono, M.
dc.contributor.authorOgihara, T.
dc.contributor.authorChambers, J.C.
dc.contributor.authorZhang, W.
dc.contributor.authorKooner, J.S.
dc.contributor.authorAlbrecht, E.
dc.contributor.authorYamamoto, K.
dc.contributor.authorKubo, M.
dc.contributor.authorNakamura, Y.
dc.contributor.authorKamatani, N.
dc.contributor.authorKato, N.
dc.contributor.authorHe, J.
dc.contributor.authorChen, Y.-T.
dc.contributor.authorCho, Y.S.
dc.contributor.authorTai, E.-S.
dc.contributor.authorTanaka, T.
dc.date.accessioned2014-11-25T09:06:19Z
dc.date.available2014-11-25T09:06:19Z
dc.date.issued2012-08
dc.identifier.citationOkada, Y., Sim, X., Go, M.J., Wu, J.-Y., Gu, D., Takeuchi, F., Takahashi, A., Maeda, S., Tsunoda, T., Chen, P., Lim, S.-C., Wong, T.-Y., Liu, J., Young, T.L., Aung, T., Seielstad, M., Teo, Y.-Y., Kim, Y.J., Lee, J.-Y., Han, B.-G., Kang, D., Chen, C.-H., Tsai, F.-J., Chang, L.-C., Cathy Fann, S.-J.C., Mei, H., Rao, D.C., Hixson, J.E., Chen, S., Katsuya, T., Isono, M., Ogihara, T., Chambers, J.C., Zhang, W., Kooner, J.S., Albrecht, E., Yamamoto, K., Kubo, M., Nakamura, Y., Kamatani, N., Kato, N., He, J., Chen, Y.-T., Cho, Y.S., Tai, E.-S., Tanaka, T. (2012-08). Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. Nature Genetics 44 (8) : 904-909. ScholarBank@NUS Repository. https://doi.org/10.1038/ng.2352
dc.identifier.issn10614036
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/108209
dc.description.abstractChronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital-or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10-8). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function. © 2012 Nature America, Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1038/ng.2352
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.contributor.departmentLIFE SCIENCES INSTITUTE
dc.contributor.departmentOPHTHALMOLOGY
dc.description.doi10.1038/ng.2352
dc.description.sourcetitleNature Genetics
dc.description.volume44
dc.description.issue8
dc.description.page904-909
dc.description.codenNGENE
dc.identifier.isiut000306854700016
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