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Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neuroscience.2003.10.050
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dc.titleSpermine reduces infarction and neurological deficit following a rat model of middle cerebral artery occlusion: A magnetic resonance imaging study
dc.contributor.authorShirhan, M.D.
dc.contributor.authorMoochhala, S.M.
dc.contributor.authorNg, P.-Y.
dc.contributor.authorLu, J.
dc.contributor.authorNg, K.C.
dc.contributor.authorTeo, A.L.
dc.contributor.authorYap, E.
dc.contributor.authorNg, I.
dc.contributor.authorHwang, P.
dc.contributor.authorLim, T.
dc.contributor.authorSitoh, Y.Y.
dc.contributor.authorRumpel, H.
dc.contributor.authorJose, R.
dc.contributor.authorLing, E.
dc.date.accessioned2014-11-20T05:58:47Z
dc.date.available2014-11-20T05:58:47Z
dc.date.issued2004
dc.identifier.citationShirhan, M.D., Moochhala, S.M., Ng, P.-Y., Lu, J., Ng, K.C., Teo, A.L., Yap, E., Ng, I., Hwang, P., Lim, T., Sitoh, Y.Y., Rumpel, H., Jose, R., Ling, E. (2004). Spermine reduces infarction and neurological deficit following a rat model of middle cerebral artery occlusion: A magnetic resonance imaging study. Neuroscience 124 (2) : 299-304. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neuroscience.2003.10.050
dc.identifier.issn03064522
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/108092
dc.description.abstractThe role of nitric oxide (NO) in post-ischemic cerebral infarction has been extensively examined, but few studies have investigated its role on the neurological deficit. In the present study, we investigated the effect of spermine on the temporal evolution of infarct volume, NO production and neurological deficit using magnetic resonance imaging in a model of permanent focal cerebral ischemia in rats. Spermine given at 10 mg/kg 2 h after ischemia reduced the infarct volume by 40% and abolished brain NO production and improved the neurological score 24 h, 48 h and 72 h after ischemia. Spermine also reduced the neurological deficit as evaluated by rotamex, grip strength and neurological severity score tests. © 2004 IBRO. Published by Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.neuroscience.2003.10.050
dc.sourceScopus
dc.subjectMRI
dc.subjectNitric oxide
dc.subjectPolyamine
dc.subjectTTC staining
dc.typeArticle
dc.contributor.departmentPHARMACOLOGY
dc.contributor.departmentANATOMY
dc.description.doi10.1016/j.neuroscience.2003.10.050
dc.description.sourcetitleNeuroscience
dc.description.volume124
dc.description.issue2
dc.description.page299-304
dc.description.codenNRSCD
dc.identifier.isiut000220079300004
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