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Title: Treatment with Met-RANTES reduces lung injury in caerulein-induced pancreatitis
Authors: Bhatia, M. 
Proudfoot, A.E.I.
Wells, T.N.C.
Christmas, S.
Neoptolemos, J.P.
Slavin, J.
Issue Date: 1-Jun-2003
Citation: Bhatia, M., Proudfoot, A.E.I., Wells, T.N.C., Christmas, S., Neoptolemos, J.P., Slavin, J. (2003-06-01). Treatment with Met-RANTES reduces lung injury in caerulein-induced pancreatitis. British Journal of Surgery 90 (6) : 698-704. ScholarBank@NUS Repository.
Abstract: Background: Severe acute pancreatitis leads to a systemic inflammatory response Characterized by widespread leucocyte activation and, as a consequence, distant lung injury. In CC chemokines the first two cysteine residues are adjacent to each other. The aim of this study was to evaluate the effect of Met-RANTES, a CC chemokine receptor antagonist, on pancreatic inflammation and lung injury in caerulein-induced acute pancreatitis in mice. Methods: Acute pancreatitis was induced in mice by hourly intraperitoneal injection of caerulein. Met-RANTES was administered either 30 min before or 1 h after starting caerulein injections, and pancreatic inflammation and lung injury were assessed. There were five groups of eight mice each including controls. Results: Treatment with Met-RANTES had little effect on caerulein-induced pancreatic damage. Met-RANTES, however, reduced lung injury when given either before administration of caerulein (mean(s.e.m.) lung myeloperoxidase (MPO) 1.47(0.19) versus 3.70(0.86)-fold increase over control, P = 0.024; mean(s.e.m.) microvascular permeability 1.15(0.05) versus 3.57(0.63) lavage to plasma fluorescein isothiocyanate-labelled albumin fluorescence ratio (L/P) per cent, P = 0.002) or after caerulein administration (lung MPO 1.96(0.27) versus 3.65(0.63)-fold increase over control, P = 0.029; microvascular permeability 0.94(0.04) versus 2.85(0.34) L/P per cent, P < 0.001). Conclusion: Treatment with Met-RANTES reduces lung damage associated with caerulein-induced pancreatitls in mice. Chemokine receptor antagonists may be of use for the treatment of the systemic complications of acute pancreatitis.
Source Title: British Journal of Surgery
ISSN: 00071323
DOI: 10.1002/bjs.4102
Appears in Collections:Staff Publications

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