Please use this identifier to cite or link to this item:
|Title:||Treatment with Met-RANTES reduces lung injury in caerulein-induced pancreatitis||Authors:||Bhatia, M.
|Issue Date:||1-Jun-2003||Citation:||Bhatia, M., Proudfoot, A.E.I., Wells, T.N.C., Christmas, S., Neoptolemos, J.P., Slavin, J. (2003-06-01). Treatment with Met-RANTES reduces lung injury in caerulein-induced pancreatitis. British Journal of Surgery 90 (6) : 698-704. ScholarBank@NUS Repository. https://doi.org/10.1002/bjs.4102||Abstract:||Background: Severe acute pancreatitis leads to a systemic inflammatory response Characterized by widespread leucocyte activation and, as a consequence, distant lung injury. In CC chemokines the first two cysteine residues are adjacent to each other. The aim of this study was to evaluate the effect of Met-RANTES, a CC chemokine receptor antagonist, on pancreatic inflammation and lung injury in caerulein-induced acute pancreatitis in mice. Methods: Acute pancreatitis was induced in mice by hourly intraperitoneal injection of caerulein. Met-RANTES was administered either 30 min before or 1 h after starting caerulein injections, and pancreatic inflammation and lung injury were assessed. There were five groups of eight mice each including controls. Results: Treatment with Met-RANTES had little effect on caerulein-induced pancreatic damage. Met-RANTES, however, reduced lung injury when given either before administration of caerulein (mean(s.e.m.) lung myeloperoxidase (MPO) 1.47(0.19) versus 3.70(0.86)-fold increase over control, P = 0.024; mean(s.e.m.) microvascular permeability 1.15(0.05) versus 3.57(0.63) lavage to plasma fluorescein isothiocyanate-labelled albumin fluorescence ratio (L/P) per cent, P = 0.002) or after caerulein administration (lung MPO 1.96(0.27) versus 3.65(0.63)-fold increase over control, P = 0.029; microvascular permeability 0.94(0.04) versus 2.85(0.34) L/P per cent, P < 0.001). Conclusion: Treatment with Met-RANTES reduces lung damage associated with caerulein-induced pancreatitls in mice. Chemokine receptor antagonists may be of use for the treatment of the systemic complications of acute pancreatitis.||Source Title:||British Journal of Surgery||URI:||http://scholarbank.nus.edu.sg/handle/10635/108068||ISSN:||00071323||DOI:||10.1002/bjs.4102|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Oct 10, 2019
WEB OF SCIENCETM
checked on Oct 10, 2019
checked on Oct 11, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.