Please use this identifier to cite or link to this item: https://doi.org/10.1002/adfm.200500408
DC FieldValue
dc.titleFabrication and characterization of nanostructured and thermosensitive polymer membranes for wound healing and cell grafting
dc.contributor.authorWang, L.-S.
dc.contributor.authorChow, P.-Y.
dc.contributor.authorPhan, T.-T.
dc.contributor.authorLim, I.J.
dc.contributor.authorYang, Y.-Y.
dc.date.accessioned2014-11-20T03:16:57Z
dc.date.available2014-11-20T03:16:57Z
dc.date.issued2006-06-06
dc.identifier.citationWang, L.-S., Chow, P.-Y., Phan, T.-T., Lim, I.J., Yang, Y.-Y. (2006-06-06). Fabrication and characterization of nanostructured and thermosensitive polymer membranes for wound healing and cell grafting. Advanced Functional Materials 16 (9) : 1171-1178. ScholarBank@NUS Repository. https://doi.org/10.1002/adfm.200500408
dc.identifier.issn1616301X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/107958
dc.description.abstractNanostructured, transparent, and thermosensitive membranes synthesized by bicontinuous microemulsion polymerization of N-isopropylacrylamide (NIPAAm), methyl methacrylate (MMA), and 2-hydroxyethyl methacrylate (HEMA) using a polymerizable nonionic surfactant, ω-methoxy poly(ethylene oxide) 40 undecyl α-methacrylate macromonomer have recently been reported. In this study, the synthesis and characterization of membranes with various compositions are presented in detail, focusing on the effects of environmental temperature and membrane composition on surface hydrophilicity, cell attachment, and detachment. The membranes synthesized with differing compositions have a nanoporous structure, and are transparent and thermosensitive in their swelling ratio and cell-attachment characteristics. Decreasing the environmental temperature and the MMA content leads to an increase in the wettability of the membrane surface. In addition, both L929 murine neoplastic fibro-blasts and primary human dermal fibroblasts can attach to and detach from the membranes with varying temperature. High cell-attachment and -detachment efficiencies are achieved by optimizing membrane composition and environmental temperature. In addition, the membranes do not show significant cytotoxicity. These membranes have great potential for the construction of a new generation of dressings and cell-delivery systems for wound healing. © 2006 WILEY-VCH Verlag GmbH & Co. KGaA.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/adfm.200500408
dc.sourceScopus
dc.typeConference Paper
dc.contributor.departmentSURGERY
dc.description.doi10.1002/adfm.200500408
dc.description.sourcetitleAdvanced Functional Materials
dc.description.volume16
dc.description.issue9
dc.description.page1171-1178
dc.description.codenAFMDC
dc.identifier.isiut000238264800006
Appears in Collections:Staff Publications

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