Please use this identifier to cite or link to this item:
|dc.title||Structural stability of neoangiogenic intramyocardial microvessels supports functional recovery in chronic ischemic myocardium|
|dc.identifier.citation||Shim, W.S.N., Lim, S.Y., Li, S.Q., Gu, Y., Ong, H.C., Song, I.C., Chuah, S.C., Wong, P. (2008-07). Structural stability of neoangiogenic intramyocardial microvessels supports functional recovery in chronic ischemic myocardium. Journal of Molecular and Cellular Cardiology 45 (1) : 70-80. ScholarBank@NUS Repository. https://doi.org/10.1016/j.yjmcc.2008.04.007|
|dc.description.abstract||We hypothesize that combining angiopoietin-1 (ANG-1) or ANG-2 with vascular endothelial growth factor (VEGF) improves myocardial perfusion and contractile function by modulating vascular adaptation of neoangiogenic microvessels in a chronic ischemic swine model. Four weeks after occlusion of the left circumflex coronary artery (LCx), animals were injected with AdVEGF165 (n = 6), AdVEGF165+AdANG-1 (n = 6), AdVEGF165+AdANG-2 (n = 6) or control vector (n = 5) into the left ventricular posterolateral wall. Regional perfusion by fluorescent microspheres and segmental myocardial tissue velocity by tissue Doppler imaging (TDI) were assessed at baseline, 4 weeks post occlusion and 4 weeks post therapy. Despite similar vascular growth following VEGF+ANG-1 and VEGF+ANG-2 treatments, transmural myocardial contractility improved only when VEGF was paired with ANG-1. In contrast, regional systolic function deteriorated uniformly across subepicardial, mid-myocardial and subendocardial segments in VEGF and VEGF+ANG-2 treated groups. Contractile improvement was associated with enhanced vascular stability through augmented arteriole formation, tight structural integration between VE-cadherin and β-catenin at endothelial junctions and improved cross-talk between endothelium and myocardium. Structural stability of developing intramyocardial microvessels contributes to systolic function during ischemic neovascularization. Coordinated regulation of angiogenic revascularization that supports vascular stability is a key aspect in improving therapeutic outcomes in ischemic myocardium. © 2008 Elsevier Inc. All rights reserved.|
|dc.description.sourcetitle||Journal of Molecular and Cellular Cardiology|
|Appears in Collections:||Staff Publications|
Show simple item record
Files in This Item:
There are no files associated with this item.
checked on Jul 12, 2019
WEB OF SCIENCETM
checked on Jul 5, 2019
checked on Jun 28, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.