Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.yjmcc.2008.04.007
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dc.titleStructural stability of neoangiogenic intramyocardial microvessels supports functional recovery in chronic ischemic myocardium
dc.contributor.authorShim, W.S.N.
dc.contributor.authorLim, S.Y.
dc.contributor.authorLi, S.Q.
dc.contributor.authorGu, Y.
dc.contributor.authorOng, H.C.
dc.contributor.authorSong, I.C.
dc.contributor.authorChuah, S.C.
dc.contributor.authorWong, P.
dc.date.accessioned2014-11-20T03:16:42Z
dc.date.available2014-11-20T03:16:42Z
dc.date.issued2008-07
dc.identifier.citationShim, W.S.N., Lim, S.Y., Li, S.Q., Gu, Y., Ong, H.C., Song, I.C., Chuah, S.C., Wong, P. (2008-07). Structural stability of neoangiogenic intramyocardial microvessels supports functional recovery in chronic ischemic myocardium. Journal of Molecular and Cellular Cardiology 45 (1) : 70-80. ScholarBank@NUS Repository. https://doi.org/10.1016/j.yjmcc.2008.04.007
dc.identifier.issn00222828
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/107948
dc.description.abstractWe hypothesize that combining angiopoietin-1 (ANG-1) or ANG-2 with vascular endothelial growth factor (VEGF) improves myocardial perfusion and contractile function by modulating vascular adaptation of neoangiogenic microvessels in a chronic ischemic swine model. Four weeks after occlusion of the left circumflex coronary artery (LCx), animals were injected with AdVEGF165 (n = 6), AdVEGF165+AdANG-1 (n = 6), AdVEGF165+AdANG-2 (n = 6) or control vector (n = 5) into the left ventricular posterolateral wall. Regional perfusion by fluorescent microspheres and segmental myocardial tissue velocity by tissue Doppler imaging (TDI) were assessed at baseline, 4 weeks post occlusion and 4 weeks post therapy. Despite similar vascular growth following VEGF+ANG-1 and VEGF+ANG-2 treatments, transmural myocardial contractility improved only when VEGF was paired with ANG-1. In contrast, regional systolic function deteriorated uniformly across subepicardial, mid-myocardial and subendocardial segments in VEGF and VEGF+ANG-2 treated groups. Contractile improvement was associated with enhanced vascular stability through augmented arteriole formation, tight structural integration between VE-cadherin and β-catenin at endothelial junctions and improved cross-talk between endothelium and myocardium. Structural stability of developing intramyocardial microvessels contributes to systolic function during ischemic neovascularization. Coordinated regulation of angiogenic revascularization that supports vascular stability is a key aspect in improving therapeutic outcomes in ischemic myocardium. © 2008 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.yjmcc.2008.04.007
dc.sourceScopus
dc.subjectIschemia
dc.subjectMyocardial contractility
dc.subjectVascular adaptation
dc.subjectVascular stability
dc.typeArticle
dc.contributor.departmentSURGERY
dc.description.doi10.1016/j.yjmcc.2008.04.007
dc.description.sourcetitleJournal of Molecular and Cellular Cardiology
dc.description.volume45
dc.description.issue1
dc.description.page70-80
dc.description.codenJMCDA
dc.identifier.isiut000257543800008
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