Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/107758
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dc.titleBrain phenolsulfotransferase (PST) activity in spontaneously hypertensive and normotensive rats
dc.contributor.authorMok, J.S.L.
dc.contributor.authorHutchinson, J.S.
dc.contributor.authorWong, K.P.
dc.date.accessioned2014-11-10T09:52:11Z
dc.date.available2014-11-10T09:52:11Z
dc.date.issued1990
dc.identifier.citationMok, J.S.L., Hutchinson, J.S., Wong, K.P. (1990). Brain phenolsulfotransferase (PST) activity in spontaneously hypertensive and normotensive rats. Biogenic Amines 7 (5) : 475-481. ScholarBank@NUS Repository.
dc.identifier.issn01688561
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/107758
dc.description.abstractPhenolsulfotransferase (PST, EC 2.8.2.1) activity was measured with dopamine as substrate in homogenates of different brain areas in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats. Dopamine 35sulfate so formed was separated from the sulfate donor, 3'-phosphoadenosine-5'-phosphosulfate (PAP 35S) by paper chromatography and quantitated by liquid scintillation counting. The four brain regions examined, namely the hypothalamus, striatum, cortex and brain stem showed marked regional variations of PST activity with the highest value in the hypothalamus. The PST activities in these brain areas of SHR were not significantly different from the corresponding values in normotensive WKY controls. From this study, it would appear that the PST activity in the rat brain does not play a role in the pathogenesis and/or maintenance of hypertension in SHR.
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentBIOCHEMISTRY
dc.description.sourcetitleBiogenic Amines
dc.description.volume7
dc.description.issue5
dc.description.page475-481
dc.description.codenBIAME
dc.identifier.isiutNOT_IN_WOS
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