Please use this identifier to cite or link to this item: https://doi.org/10.1089/ars.2007.1865
Title: Is antioxidant potential of the mitochondrial targeted ubiquinone derivative MitoQ conserved in cells lacking mtDNA?
Authors: Lu, C. 
Zhang, D.
Whiteman, M.
Armstrong, J.S. 
Issue Date: 1-Mar-2008
Citation: Lu, C., Zhang, D., Whiteman, M., Armstrong, J.S. (2008-03-01). Is antioxidant potential of the mitochondrial targeted ubiquinone derivative MitoQ conserved in cells lacking mtDNA?. Antioxidants and Redox Signaling 10 (3) : 651-660. ScholarBank@NUS Repository. https://doi.org/10.1089/ars.2007.1865
Abstract: MitoQ has been developed as a mitochondrial targeted antioxidant for diseases associated with oxidative stress. Here we show that MitoQ blocks the generation of reactive oxygen species (ROS) and mitochondrial protein thiol oxidation, and preserves mitochondrial function and ultrastructure after glutathione (GSH) depletion. Furthermore, the antioxidant effect of MitoQ is conserved in cells lacking mitochondrial DNA, indicating that its antioxidant properties do not depend on a functional electron transport chain (ETC). Our results elucidate the antioxidant mechanism of MitoQ and suggest that it may be a useful therapeutic for disorders associated with a dysfunctional ETC and increased ROS production. © 2008 Mary Ann Liebert, Inc.
Source Title: Antioxidants and Redox Signaling
URI: http://scholarbank.nus.edu.sg/handle/10635/107752
ISSN: 15230864
DOI: 10.1089/ars.2007.1865
Appears in Collections:Staff Publications

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