Please use this identifier to cite or link to this item: https://doi.org/10.1073/pnas.0405928102
DC FieldValue
dc.titleThe Wnt/β-catenin signaling pathway targets PPARγ activity in colon cancer cells
dc.contributor.authorJansson, E.Å.
dc.contributor.authorAre, A.
dc.contributor.authorGreicius, G.
dc.contributor.authorKuo, I.-C.
dc.contributor.authorKelly, D.
dc.contributor.authorArulampalam, V.
dc.contributor.authorPettersson, S.
dc.date.accessioned2014-11-06T08:51:05Z
dc.date.available2014-11-06T08:51:05Z
dc.date.issued2005-02-01
dc.identifier.citationJansson, E.Å., Are, A., Greicius, G., Kuo, I.-C., Kelly, D., Arulampalam, V., Pettersson, S. (2005-02-01). The Wnt/β-catenin signaling pathway targets PPARγ activity in colon cancer cells. Proceedings of the National Academy of Sciences of the United States of America 102 (5) : 1460-1465. ScholarBank@NUS Repository. https://doi.org/10.1073/pnas.0405928102
dc.identifier.issn00278424
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/107559
dc.description.abstractControl of colon cell fate in adenocarcinomas is disrupted, in part, due to aberrant Wnt/β-catenin signaling. The nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ) has been implicated in the development of colon cancers. In the adenomatous polyposis coli multiple intestinal neoplasia (APC Min) mouse cancer model, PPARγ expression in the colonic mucosa is markedly altered. In addition, PPARγ protein levels are elevated, possibly through sequestration by activated β-catenin in colon cancer cell lines. Induction of the Wnt/β-catenin pathway by LiCl also elevated PPARγ levels and induced PPARγ-dependent reporter and endog-enous target genes. Mechanistically, PPARγ, through interactions with β-catenin and T cell transcription factor (Tcf)-4, may be a determinant of cell fate and is likely a target of the Wnt pathway in cancer cells.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1073/pnas.0405928102
dc.sourceScopus
dc.subjectAPC Min mice
dc.subjectColon epithelium
dc.subjectNuclear receptors
dc.subjectT cell transcription factor 4
dc.subjectWnt signaling
dc.typeArticle
dc.contributor.departmentPAEDIATRICS
dc.description.doi10.1073/pnas.0405928102
dc.description.sourcetitleProceedings of the National Academy of Sciences of the United States of America
dc.description.volume102
dc.description.issue5
dc.description.page1460-1465
dc.description.codenPNASA
dc.identifier.isiut000226877300039
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