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Title: Association between serum amyloid A and obesity: A meta-analysis and systematic review
Authors: Zhao, Y.
He, X.
Shi, X.
Huang, C.
Liu, J.
Zhou, S.
Heng, C.-K. 
Keywords: Adipose
Serum amyloid A
Weight loss
Issue Date: May-2010
Citation: Zhao, Y., He, X., Shi, X., Huang, C., Liu, J., Zhou, S., Heng, C.-K. (2010-05). Association between serum amyloid A and obesity: A meta-analysis and systematic review. Inflammation Research 59 (5) : 323-334. ScholarBank@NUS Repository.
Abstract: Background Emerging evidence indicates an association of the acute-phase protein serum amyloid A (SAA) with obesity. Here we review and summarize quantitatively the available data related to this association. Methods PubMed was systematically searched using the terms "serum amyloid A" and "obesity." Eighty-one relevant studies between January 1966 and July 2009 were identified. Of these, only 11 cross-sectional studies and 10 prospective studies with successful interventions met our inclusion criteria for the meta-analysis. All analyses were conducted using the Comprehensive Meta-Analysis software. Literature pertaining to the relationship between SAA and other inflammatory markers, and the association between SAA and obesity-related disorders, such as cardiovascular diseases, atherosclerosis, diabetes, and insulin resistance was also reviewed. Results A strong association between body mass index and SAA levels was found in the 11 cross-sectional studies. The overall correlation coefficient is 0.230 (95% CI 0.160-0.297, P<0.0005). The ten prospective studies were subsequently analyzed, and the difference in SAA levels before and after weight loss, expressed as standardized mean difference was-0.480 (95% CI-0.678 to-0.283, P<0.0005). We discuss some potential underlying mechanisms and clinical applications for reducing SAA levels in obesity. © 2009 Birkhäuser Verlag, Basel/Switzerland.
Source Title: Inflammation Research
ISSN: 10233830
DOI: 10.1007/s00011-010-0163-y
Appears in Collections:Staff Publications

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