Please use this identifier to cite or link to this item: https://doi.org/10.1016/0041-0101(96)00062-1
Title: Neuroblastoma cell culture assay shows that Carcinoscorpius rotundicauda haemolymph neutralizes tetrodotoxin
Authors: Yeo, D.S.A.
Ding, J.L. 
Bow, H.
Issue Date: Sep-1996
Citation: Yeo, D.S.A., Ding, J.L., Bow, H. (1996-09). Neuroblastoma cell culture assay shows that Carcinoscorpius rotundicauda haemolymph neutralizes tetrodotoxin. Toxicon 34 (9) : 1054-1057. ScholarBank@NUS Repository. https://doi.org/10.1016/0041-0101(96)00062-1
Abstract: Veratridine facilitates the influx of Na+ into Neuro-2A cells and this process is exacerbated by the presence of a Na+/K+-ATPase inhibitor, ouabain, leading to a reduction in cell viability. However, tetrodotoxin neutralizes the cytotoxic effects of veratridine, hence sustaining the viability of Neuro-2A cells. This neutralizing ability was negated when TTX was first reacted with cell-free haemolymph of Carcinoscorpius rotundicauda, resulting in reduced cell viability. These results therefore indicate a bona fide effect of the cell-free haemolymph against tetrodotoxin as demonstrated by in vitro cell culture technique.
Source Title: Toxicon
URI: http://scholarbank.nus.edu.sg/handle/10635/106854
ISSN: 00410101
DOI: 10.1016/0041-0101(96)00062-1
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