Please use this identifier to cite or link to this item: https://doi.org/10.1007/BF01966447
Title: Effect of carrageenan-induced acute inflammation on corticosterone levels in mice
Authors: Sin, Y.M. 
Chio, S.L.
Issue Date: Mar-1990
Citation: Sin, Y.M., Chio, S.L. (1990-03). Effect of carrageenan-induced acute inflammation on corticosterone levels in mice. Agents and Actions 29 (3-4) : 196-200. ScholarBank@NUS Repository. https://doi.org/10.1007/BF01966447
Abstract: Changes in corticosterone levels in plasma and inflammatory exudase were studied in the 6-day-old air pouch of mice. The pouch inflammation in the test group was induced by the injection of carrageenan prepared in physiological saline while the control received only the physiological saline. The results show that exudate and plasma of both groups showed a rapid rise in corticosterone as measured after 30 min and this early rise was probably due to the resulting effect of the ether used during the injection of irritant or vehicle. In contrast, corticosterone levels in the inflammatory exudate of the test group increased with time, reaching a peak at 24 hours after the carrageenan injection. The increased corticosterone levels in the inflammatory exudate appeared to be closely correlated with the increased exudate cell accumulation. This suggests that the increased accumulation of exudate corticosterone in the pouch might play an important role at the inflammatory site by modulating intensity of the inflammatory reactivity caused by the irritant. © 1990 Birkhäuser Verlag.
Source Title: Agents and Actions
URI: http://scholarbank.nus.edu.sg/handle/10635/106784
ISSN: 00654299
DOI: 10.1007/BF01966447
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