Please use this identifier to cite or link to this item:
Title: Changes in corticosterone levels under different degrees of acute inflammation in mice
Authors: Chio, S.L.
Sin, Y.M. 
Issue Date: May-1992
Citation: Chio, S.L., Sin, Y.M. (1992-05). Changes in corticosterone levels under different degrees of acute inflammation in mice. Agents and Actions 36 (1-2) : 93-98. ScholarBank@NUS Repository.
Abstract: Carrageenan of different concentrations was injected into the 6-day-old air pouch in mice. It was found that 12 mg carrageenan caused a significant increase of plasma and exudate corticosterone levels at 24 h, while 1 and 3 mg carrageenan could only induce a significant increase of exudate corticosterone at 4 h. Elevation of corticosterone in both plasma and inflammatory exudate appeared to be correlated, suggesting that the exudate corticosterone was derived from the blood circulation. Injection of exogenous histamine and PGE2 into the air pouch induced a significant increase in exudate levels of corticosterone. However, plasma corticosterone increased significantly only after histamine administration, although a slight increase was observed in those injected with PGE2. These findings thus suggest that endogenous histamine and PGE2 which are released during carrageenan-induced acute inflammation, as shown in our previous work, might be responsible for the increase of corticosterone in both plasma and inflammatory exudate. © 1992 Birkhäuser Verlag.
Source Title: Agents and Actions
ISSN: 00654299
DOI: 10.1007/BF01991235
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Dec 10, 2019


checked on Dec 3, 2019

Page view(s)

checked on Dec 14, 2019

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.