Please use this identifier to cite or link to this item: https://doi.org/10.1039/b916705f
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dc.titleSynthetic hydrogels for controlled stem cell differentiation
dc.contributor.authorLiu, S.Q.
dc.contributor.authorTay, R.
dc.contributor.authorKhan, M.
dc.contributor.authorRachel Ee, P.L.
dc.contributor.authorHedrick, J.L.
dc.contributor.authorYang, Y.Y.
dc.date.accessioned2014-10-29T02:04:06Z
dc.date.available2014-10-29T02:04:06Z
dc.date.issued2009
dc.identifier.citationLiu, S.Q., Tay, R., Khan, M., Rachel Ee, P.L., Hedrick, J.L., Yang, Y.Y. (2009). Synthetic hydrogels for controlled stem cell differentiation. Soft Matter 6 (1) : 67-81. ScholarBank@NUS Repository. https://doi.org/10.1039/b916705f
dc.identifier.issn1744683X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/106710
dc.description.abstractStem cells offer great promise for regenerative medicine because of their pluripotency and their ability for self-renewal; however, their use in clinical treatments requires knowledge of the cues that control stem cell fate in vivo, and the ability to recapitulate those cues in tissue-engineered systems to direct differentiation into desired cell types and tissues. Hydrogels formed from poly(ethylene glycol) (PEG) are useful as scaffolds for promoting stem cell growth and differentiation towards the formation of tissues. The mechanical and biochemical microenvironment of these PEG hydrogels can be modified in a variety of ways to control cellular functions that are important in determining and maintaining stem cell phenotype. In this review, recent advances in the synthesis and modification of PEG hydrogels will be presented, along with important physicochemical considerations in the design of these hydrogels to better mimic the stem cell microenvironment and direct stem cell differentiation. © The Royal Society of Chemistry 2010.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1039/b916705f
dc.sourceScopus
dc.typeReview
dc.contributor.departmentPHARMACY
dc.description.doi10.1039/b916705f
dc.description.sourcetitleSoft Matter
dc.description.volume6
dc.description.issue1
dc.description.page67-81
dc.identifier.isiut000272843200003
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