Please use this identifier to cite or link to this item: https://doi.org/10.1517/17425247.2011.610304
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dc.titleSpray granulation for drug formulation
dc.contributor.authorLoh, Z.H.
dc.contributor.authorEr, D.Z.L.
dc.contributor.authorChan, L.W.
dc.contributor.authorLiew, C.V.
dc.contributor.authorHeng, P.W.S.
dc.date.accessioned2014-10-29T02:04:03Z
dc.date.available2014-10-29T02:04:03Z
dc.date.issued2011-12
dc.identifier.citationLoh, Z.H., Er, D.Z.L., Chan, L.W., Liew, C.V., Heng, P.W.S. (2011-12). Spray granulation for drug formulation. Expert Opinion on Drug Delivery 8 (12) : 1645-1661. ScholarBank@NUS Repository. https://doi.org/10.1517/17425247.2011.610304
dc.identifier.issn17425247
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/106705
dc.description.abstractIntroduction: Granulation is a key unit process in the production of pharmaceutical solid dosage forms and involves the agglomeration of fine particles with the aid of a binding agent. Fluidized bed granulation, a classic example of spray granulation, is a technique of particle agglomeration brought about by the spray addition of the binding liquid onto a stationary bed of powder particles that is transformed to a fluid-like state by the passage of air through it. Areas covered: The basic working principles, equipment set-up, advantages and challenges of fluidized bed granulation are introduced in this review. This is followed by an overview of the formulation and process-related variables affecting granulation performance. Technological advances, particularly in the application of process analytical tools, in the field of fluidized bed granulation research are also discussed. Expert opinion: Fluidized bed granulation is a popular technique for pharmaceutical production, as it is a highly economical and efficient one-pot process. The research and development of process analytical technologies (PAT) has allowed greater process understanding and control to be achieved, even for the lesser known fluidized bed techniques, such as bottom spray and fluidized hot melt granulation. In view of its consistent mixing, as well as continuous and concurrent wetting and drying occurring throughout processing, fluidized bed granulation shows great potential for continuous production although more research is required to fully implement, validate and integrate the PAT tools in a production line. © 2011 Informa UK, Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1517/17425247.2011.610304
dc.sourceScopus
dc.subjectFluidized bed granulation
dc.subjectGranulation
dc.subjectPharmaceutical manufacturing
dc.subjectProcess analytical technology
dc.subjectSolid dosage forms
dc.typeReview
dc.contributor.departmentPHARMACY
dc.description.doi10.1517/17425247.2011.610304
dc.description.sourcetitleExpert Opinion on Drug Delivery
dc.description.volume8
dc.description.issue12
dc.description.page1645-1661
dc.identifier.isiut000297224500008
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