Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.drudis.2006.03.012
DC FieldValue
dc.titleProgress and problems in the exploration of therapeutic targets
dc.contributor.authorZheng, C.
dc.contributor.authorHan, L.
dc.contributor.authorYap, C.W.
dc.contributor.authorXie, B.
dc.contributor.authorChen, Y.
dc.date.accessioned2014-10-29T02:03:54Z
dc.date.available2014-10-29T02:03:54Z
dc.date.issued2006-05
dc.identifier.citationZheng, C., Han, L., Yap, C.W., Xie, B., Chen, Y. (2006-05). Progress and problems in the exploration of therapeutic targets. Drug Discovery Today 11 (9-10) : 412-420. ScholarBank@NUS Repository. https://doi.org/10.1016/j.drudis.2006.03.012
dc.identifier.issn13596446
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/106699
dc.description.abstractDrugs exert their therapeutic effect by binding and regulating the activity of a particular protein or nucleic acid target. A large number of targets have been explored for drug discovery. Continuous effort has been directed at the search for new targets and more-extensive exploration of existing targets. Knowledge of these targets facilitates the understanding of molecular mechanisms of drugs and the effort required for drug discovery and target searches. Areas of progress, current focuses of research and development and the difficulties in target exploration are reviewed. The characteristics of the currently explored targets and their correlation to the level of difficulty for target exploration are analyzed. From these characteristics, simple rules can be derived for estimating the difficulty level of target exploration. The feasibility of predicting druggable proteins by using simple rules and sequence-derived physicochemical properties is also discussed. © 2006 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.drudis.2006.03.012
dc.sourceScopus
dc.typeReview
dc.contributor.departmentPHARMACY
dc.description.doi10.1016/j.drudis.2006.03.012
dc.description.sourcetitleDrug Discovery Today
dc.description.volume11
dc.description.issue9-10
dc.description.page412-420
dc.description.codenDDTOF
dc.identifier.isiut000238447300008
Appears in Collections:Staff Publications

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