Please use this identifier to cite or link to this item: https://doi.org/10.1080/03639040801974295
Title: Chick chorioallantoic membrane as an in situ biological membrane for pharmaceutical formulation development: A review
Authors: Saw, C.L.L.
Heng, P.W.S. 
Liew, C.V. 
Keywords: Chick chorioallantoic membrane
Draize test
Drug delivery
Formulation development
Permeation
Transport study
Issue Date: Nov-2008
Citation: Saw, C.L.L., Heng, P.W.S., Liew, C.V. (2008-11). Chick chorioallantoic membrane as an in situ biological membrane for pharmaceutical formulation development: A review. Drug Development and Industrial Pharmacy 34 (11) : 1168-1177. ScholarBank@NUS Repository. https://doi.org/10.1080/03639040801974295
Abstract: The use of animals in research has always been a debatable issue. Over the past few decades, efforts have been made to reduce, replace, and refine experiments for ethical use of experimental animals. The use of chick chorioallantoic membrane (CAM) was one of the proposed alternatives to the Draize rabbit ocular irritation test with several advantages including simplicity, rapidity, sensitivity, ease of performance, and cost-effectiveness. The recent use of CAM in the development of pharmaceuticals and testing models to mimic human tissue, including drug transport across CAM, will be discussed in this review. Copyright © Informa UK, Ltd.
Source Title: Drug Development and Industrial Pharmacy
URI: http://scholarbank.nus.edu.sg/handle/10635/106621
ISSN: 03639045
DOI: 10.1080/03639040801974295
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