Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.carbpol.2011.11.012
DC FieldValue
dc.titleAlginates as a useful natural polymer for microencapsulation and therapeutic applications
dc.contributor.authorGoh, C.H.
dc.contributor.authorHeng, P.W.S.
dc.contributor.authorChan, L.W.
dc.date.accessioned2014-10-29T02:02:27Z
dc.date.available2014-10-29T02:02:27Z
dc.date.issued2012-03-17
dc.identifier.citationGoh, C.H., Heng, P.W.S., Chan, L.W. (2012-03-17). Alginates as a useful natural polymer for microencapsulation and therapeutic applications. Carbohydrate Polymers 88 (1) : 1-12. ScholarBank@NUS Repository. https://doi.org/10.1016/j.carbpol.2011.11.012
dc.identifier.issn01448617
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/106609
dc.description.abstractThis review outlines the role of alginates in microencapsulation and therapeutic applications. It focuses on the physicochemical properties of alginates (e.g. viscosity, thermo-stability, sol-gel transformation and drug release) to gain better insight into their potential medical applications, particularly for wound care and therapeutics. In order to understand how alginates can be optimized as a useful delivery system for therapeutic applications, various factors that impact drug release from alginate matrices (e.g. types of cations used in cross-linking, porosity of alginate matrices, pH effect, alginate composition, molecular weight of encapsulated drugs and modification of the functional groups in alginates) are also discussed. More specifically, practical applications of the cross-linking mechanism and sol-gel transformation property of alginates are explored to assess their potential to improve the mechanical properties of alginate dressings, to impart anti-microbial properties for treating wound infections and to develop products for tissue repair and wound healing. Innovative processes of developing alginate carriers and delivery systems and their recent applications are also discussed. Strategies employed to improve gelation of alginates commonly target the formulation by the inclusion of non-gelling cations or sequestrants during cross-linking. The application of other strategies, such as hot-made alginate gel method, in situ gelation method, crystal gun method, acoustic excitation method, and the use of extrusion devices with improved design are reviewed. © 2011 Elsevier Ltd All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.carbpol.2011.11.012
dc.sourceScopus
dc.subjectAlginates
dc.subjectInnovative methods
dc.subjectMicroencapsulation
dc.subjectPhysicochemical properties
dc.typeReview
dc.contributor.departmentPHARMACY
dc.description.doi10.1016/j.carbpol.2011.11.012
dc.description.sourcetitleCarbohydrate Polymers
dc.description.volume88
dc.description.issue1
dc.description.page1-12
dc.description.codenCAPOD
dc.identifier.isiut000300545800001
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.